摘要
目的:对黄芩提取物及其磷脂复合物和亚微乳制剂的大鼠鼻黏膜吸收进行研究,评价黄芩提取物改性技术和剂型选择的合理性。方法:采用大鼠鼻腔在体吸收法,对不同浓度黄芩提取物、黄芩提取物磷脂复合物及亚微乳的在体循环吸收量进行测定。结果:黄芩提取物、磷脂复合物、亚微乳在本实验条件下,2 h内吸收量依次改善,亚微乳制剂在体总吸收总量显著增加,属被动吸收机制。结论:黄芩提取物改性方法和亚微乳剂型选择科学合理。
Objective： To study the nasal mucosa absorption of Scutellariae Radix extract in rats and its two preparations phospholipid complex and submicron emulsion,and to evaluate the rationality of Scutellariae Radix extract modification technology and preparation form. Methods： According to the nasal absorption method,the absorption amount of Scutellariae Radix extract,phospholipid complex and submicron emulsion were determined. Results： The absorption amount of Scutellariae Radix extract,phospholipid complex and submicron emulsion under the experimental conditions was improved in turn in 2 h and the absorption amount of submicron emulsion increased significantly. The absorption characteristics were passive diffusion. Conclusion： The modification methods and preparation form of Scutellariae Radix extract were scientific and reasonable.
出处
《中药材》
CAS
CSCD
北大核心
2015年第10期2172-2175,共4页
Journal of Chinese Medicinal Materials
基金
国家"十一五"重大新药创制项目(2009ZX09103-353)
陕西省教育厅科研计划项目资助(11JK0680)
关键词
黄芩提取物
磷脂复合物
亚微乳
鼻腔吸收
Scutellariae Radix extract
Phospholipid complex
Submicron emulsion
Nasal absorption
