摘要
目的探讨吲哚美辛栓预防ERCP术后急性胰腺炎的临床效果。方法收集2011年3月~2015年9月我院行ERCP治疗的180例患者,按照随机数字表法分为两组,观察组和对照组各90例,对照组给予常规治疗措施,观察组在常规治疗措施基础上给予吲哚美辛栓预防治疗。比较两组手术前后不同时间点血清淀粉酶水平、急性胰腺炎和高淀粉酶血症的发生情况。结果观察组和对照组术后2 h、12 h、24 h的血清淀粉酶水平与术前比较均出现明显升高,且观察组升高的程度低于对照组,两组差异有统计学意义（P〈0.05）。观察组急性胰腺炎发生率及高淀粉酶血症发生率均低于对照组,两组差异有统计学意义（P〈0.05）。结论吲哚美辛可有效预防ERCP术后急性胰腺炎的发生,降低高淀粉酶血症发生率,能使血清淀粉酶水平明显降低。
Objective To investigate the clinical effect of indomethacin suppositories prevention of post-ERCP acute pancreatitis. Methods 180 cases of ERCP were selected from March 2011 to September 2015 in our hospital, all the patients according to the random number table were divided into two groups, there were 90 cases in the observation group and the control group. The control group received conventional treatment, the observation group treated with indomethacin prevention on the bases of the conventional treatment. The serum amylase levels at different time points before and after surgery, acute pancreatitis and hyperamylasemiaof two groups were compared. Results The serum amylase levels of the observation group and the control group after 2 h, after 12 h, 24 h postoperative were higher than the preoperative, the degree of elevation of the observation group was smaller than the control group, the difference was statistically significance（P〈0.05）. The incidence of acute pancreatitisand hyperamylasemia of the observation group were lower than the control group, the difference was statistically significant（P〈0.05）. Conclusion Indomethacin can be effective in preventing post-ERCP acute pancreatitis and reduce the incidence of hyperamylasemia, can significantly lower blood levels.
出处
《中国继续医学教育》
2015年第33期173-174,共2页
China Continuing Medical Education
