摘要
目的：了解232例药品不良反应（ adverse drug reaction,ADR）发生情况及相关因素,为临床合理用药提供参考. 方法：2012-2013年东莞市第五人民医院共上报广东省ADR监测中心232例ADR报告,对患者的年龄、性别、涉及药品种类、药品剂型、给药途径、累及器官和（或）系统及主要临床表现等相关因素进行统计分析. 结果：232 例 ADR患者中,男性126 例,女性106例,男女比例为1：1. 189,年龄2个月-95岁不等;共涉及药品88种,抗微生物药33种,占37. 5%,共引发ADR 127例次,占合计246例次的51. 63%;静脉滴注给药引发的ADR最多,为175例次（占合计240例次的72. 9%）;ADR的主要临床表现为皮肤及其附件损害、消化系统反应等. 结论：临床应合理使用药物,加强药品不良反应监测,以减少不良反应的发生.
OBJECTIVE：To investigate the occurrence of adverse drug reaction （ ADR ） in 232 cases and its relevant factors,and to provide clinical reference for rational drug use. METHODS： 232 cases of ADR reports were collected to the Monitoring Center of Guangdong Province by the Fifth People＇s Hospital of Dongguan during 2012-2013,the relevant factors including patients＇age and sex,drug varieties, drug form,route of administration,involved organs and（ or） systems and clinical manifestation were statistically analyzed. RESULTS： Of the 232 cases,126 cases were male and 106 cases were female,the ratio was 1：1. 189,aged from 2 months to 95 years old. 88 kinds of drugs were involved,leading the list were antimicrobial agents （33kinds,37. 5%）,which induced 127 cases of ADR and accounting for 51. 63% of the total 246 cases. Intravenous infusion induced the most cases of ADR, with 175 cases （ accounting for 72. 9% of the total 240 cases） . The main clinical manifestation of ADR was lesions of skin and its accessories,digestive system reactions etc. CONCLUSIONS： The clinic should use antimicrobial rationally,strengthen the monitoring of ADR so as to reduce the occurrence of ADR.
出处
《中国医院用药评价与分析》
2015年第8期1082-1084,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
抗微生物药
合理用药
回顾性分析
Adverse drug reaction
Antimicrobial agents
Rational drug use
Retrospective analysis
