摘要
目的研究医院重症监护病房(ICU)患者中心静脉导管相关性血流感染病原菌分布及其耐药性,为有效控制措施提供参考。方法采用细菌分离鉴定技术和药敏试验方法,对某医院ICU住院患者送检病原学标本进行检测与分析。结果从该医院ICU患者送检的血液和导管标本中共分离出病原菌227株,革兰阴性杆菌和革兰阳性球菌分别占53.74%和40.97%。表皮葡萄球菌、大肠埃希菌、铜绿假单胞菌和肺炎克雷伯菌分居前四位。同时存在真菌血流感染。革兰阴性代表菌株对阿米卡星、妥布霉素、呋喃妥因、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦和亚胺培南的耐药率较低,革兰阳性代表菌株对呋喃妥因、利福平、替加环素、利奈唑胺和万古霉素的耐药率较低。结论导管相关血流感染病原菌分布居首位的革兰阳性球菌,存在真菌感染,提示应加强耐药菌监测和药敏试验,合理使用抗菌药物。
Objective To research the pathogen distribution and drug susceptibility of intensive care unit（ ICU） patients with central venous catheter related blood stream infection（ CRBSI）,so as to provide reference for effective control measures. Methods The etiology specimens from hospital ICU patients were testing and analysis by bacteria isolation and identification technology and drug susceptibility test. Results A total of 227 strains pathogen were isolated from blood and catheter specimens of the hospital ICU patients,including gram-negative bacillus（ 53. 74%） and gram-positive cocci（ 40. 97%）. The first four were Staphylococcus epidermidis,Eschericha coli,Pseudomonas aeruginosa and Klebsiella pneumoniae respectively. Fungi bloodstream infection was existed at the same time. Drug susceptibility results showed that the gram-negative representative strains was sensitive to amikacin,tobramycin,nitrofurantoin,piperacillin / tazobactam,Cefoperazone / sulbactam and imipenem,gram-positive representative strains was sensitive to nitrofurantoin,rifampicin,tigecycline,rinathiazoleamine and vancomycin. Conclusion The top of the list pathogen is gram-positive cocci of catheter related blood stream infection,fungi bloodstream infection is existed at the same time. Drug-resistant bacteria monitoring should be strengthened and antimicrobial agents should be used rationally.
出处
《中国消毒学杂志》
CAS
北大核心
2016年第1期57-59,共3页
Chinese Journal of Disinfection
关键词
中心静脉导管相关性血流感染
病原菌
耐药性
监测
central venous catheter related blood stream infections
pathogen
drug resistance
monitoring
