摘要
目的探讨婴幼儿肺炎支原体肺炎（MPP）肺外并发症的相关因素。方法将105例MPP患儿根据是否合并肺外并发症分为肺外并发症组（72例）和无肺外并发症组（33例），对两组患儿一般情况相关因素以及疾病相关因素进行单因素分析，差异有统计学意义的因素进行Logistic回归分析。结果婴幼儿MPP肺外并发症发生率68．6％（72／105），患儿主要肺外受累系统是消化系统（54．2％）、心血管系统（44．4％）以及血液系统（33．3％）。与MPP肺外并发症相关的20个因素中，年龄、喂养方式（包括人工、混合、母乳）、发病季节、发热天数、肺炎支原体（MP）-IgM滴度、C反应蛋白、红细胞沉降率、开始使用大环内酯类药物时间两组比较差异有统计学意义（P〈0．05）。多因素Logistic回归分析显示，年龄≥2岁、发热天数≥7d、MP—IgM滴度≥1：160、C反应蛋白增高、红细胞沉降率加快是婴幼儿MPP发生肺外并发症的危险因素，母乳喂养和发病7d内使用大环内酯类药物是保护因素。结论婴幼儿MPP肺外并发症发生率较高，可累及多个系统，年龄较长、热程较长、MP—IgM滴度高、C反应蛋白增高、红细胞沉降率加快以及既往病史较多的患儿肺外并发症发生率较高，临床要给予高度重视。
Objective To investigate the complications related factors in infants with mycoplasma pneumonia pulmonary（MPP）. Methods According to the condition of pulmonary complications, 105 cases of infants MPP were divided into pulmonary complication group and no pulmonary complication group with 72 eases and 33 cases respectively,and the general related factors and disease related factors of two groups were analyzed. Results The incidence rate of pulmonary complication was 68.6% （72/105） in infants MPP, and the main involved extra-pulmonary systems were digestive system （54.2%）, cardiovascular system （44.4%） and blood system（33.3%）. Among 20 factors associated with pulmonary complications of MPP, age, feeding method （including artificial, mixing and milk three classification）, season of onset, fever days, the titer of mycoplasma pneumonia （MP）-IgM, C-reaction protein, erythrocyte sedimentation rate and the initial time of using maerolides had significant differences between two groups （P 〈 0.05）. Multivariate Logistic regression analysis showed that age i〉 2 years, fever days/〉 7 d, titer of MP-IgM i〉 1 ： 160, increased C-reaction protein levels and accelerated erythrocyte sedimentation rate were the risk factors for pulmonary complications of infants MPP, while breasffeeding and using macrolides within 7 d were the protective factors. Conclusions The incidence rate of pulmonary complications in infants MPP is high, which can affect multiple systems. For children with older age, longer thermal process, higher titer of MP-IgM, and increased C-reaction protein, accelerated erythrocyte sedimentation rate and more past medical history, more attention should be paid for their higher pulmonary complications incidence.
出处
《中国医师进修杂志》
2016年第1期27-31,共5页
Chinese Journal of Postgraduates of Medicine
