摘要
骨巨细胞瘤（giant cell tumor,GCT）是较为常见的原发骨肿瘤,欧美报道约占全部原发骨肿瘤的5%[1],但来自亚洲的报道,其相对发病率似乎更高,北京积水潭医院的大宗病例报道GCT占该中心全部诊治原发骨肿瘤的13.7%[2],另外也有一些文献显示亚洲人种发病率较高[3],因此GCT的治疗在中国值得重视。
Giant cell tumor（ GCT） is a common primary bone tumor, which is locally aggressive with unpredictable behavior. It accounts for 5% of primary bone tumors and 20% of all benign tumors. However, the reported incidence in some Asian countries may be higher than others. Giant cell tumors of the bone located preferentially around the knee joint, especially in the distal femur and proximal tibia. The surgical treatment of giant cell tumors includes tumor curettage, packing of the cavity with bone cement, allograft, auto-graft or artificial bone, prosthesis or allograft reconstruction following the resection. In practice, curettage and cement reconstruction are most commonly used to treat giant cell tumors in the extremities. Extensive curettage need to be carried out as follows：（ 1） a cortical window should be made to access all possible existing tumors so as to avoid blind angle.（ 2） a highspeed burr is needed, and the residual cavity should be burred at least 10 mm into the normal cancellous bone or / and 1 mm into the normal cortical bone.（ 3） the whole curettage field should be physically washed out with flushing gun. The use of bone cement and phenol is necessary. Some reports show that packing of the cavity with bone cement can significantly reduce the recurrence rate of tumors. There are some differences in the recurrence rate of giant cell tumors in different sites. Compared with the distal femur and proximal tibia, the recurrence rate of giant cell tumor of the distal radius after curettage seems to be higher, so the treatment varies from site to site.
出处
《中国骨与关节杂志》
CAS
2016年第1期29-31,共3页
Chinese Journal of Bone and Joint
关键词
骨巨细胞瘤
四肢
骨水泥成形术
刮除术
复发
Giant cell tumor of bone
Extremities
Cementoplasty
Curettage
Recurrence
