摘要
目的探讨糖化血红蛋白（Hb A1c）与不稳定心绞痛（UA）择期冠状动脉介入治疗（PCI）患者术后发生对比剂肾病（CIN）的关系。方法选取2015年1月~2015年10月于北京安贞医院诊断UA并行择期PCI患者420例患者,根据Hb A1c水平分为实验组（Hb A1c≥6.5%,n=118）和对照组（Hb A1c〈6.5%,n=302）两组,比较两组患者术前及术后36 h血肌酐水平、内生肌酐清除率（Ccr）水平及CIN发生率,分析Hb A1c水平与不稳定性心绞痛患者择期PCI术后发生CIN的关系。结果实验组患者24.4%患者发生CIN,对照组患者0.67%发生CIN,实验组较对照组CIN发生率明显增高（P〈0.05）。二元Logistic回归分析显示Hb A1c水平≥6.5%是UA患者择期PCI术后发生CIN的独立危险因素（OR=5.711;95%CI：2.475~13.785,P=0.000）。结论不稳定心绞痛行择期冠状动脉介入治疗患者Hb A1c≥6.5%术后CIN发生率将明显升高。
Objective To discuss the relationship between glycated hemoglobin（Hb Alc） and contrastinduced nephropathy（CIN） after selective percutaneous coronary intervention（PCI） in patients with unstable angina pectoris（UAP）. Methods UAP patients treated with selected PCI（n=420） were chosen from Jan. 2015 and Oct. 2015, and the divided, according to the level of Hb Alc, into test group（Hb A1c≥6.5%, n=118） and control group（Hb A1c6.5%, n=302）. The levels of creatinine（Cr） and endogenous creatinine clearance rate（CCr）, and incidence of CIN were compared between 2 groups before and 36 h after PCI. The relationship between Hb A1 c level and CIN after PCI was analyzed. Results The incidence of CIN was 24.4% in test group and 0.67% in control group（P0.05）. The results of binary Logistic analysis showed that Hb A1 c level≥6.5% is the independent risk factor in UAP patients after selected PCI（OR=5.711; 95%CI： 2.475-13.785, P=0.000）. Conclusion The incidence of CIN increases significantly in UPA patients with Hb A1 c level≥6.5% after selected PCI.
出处
《中国循证心血管医学杂志》
2016年第1期66-68,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
糖化血红蛋白
对比剂肾病
不稳定性心绞痛
经皮冠状动脉介入治疗
Glycated hemoglobin
Contrast-induced nephropathy
Unstable angina pectoris
Percutaneous coronary intervention
