摘要
目的 3种斑点分布（瑞利分布、莱斯分布和K分布）混合下的孤立性囊肿肾脏的超声仿真研究及性能评价。方法依据肾脏组织结构,分析组织散射点三维特点、超声斑点与组织散射点分布,得到瑞利、莱斯、K分布参数模型,建立组织散点模型。用FIELDⅡ软件对其进行超声仿真。选择45例经超声检查诊断为孤立性囊肿肾脏病变患者,其中男性20例,女性25例;年龄30~75岁,平均年龄51岁。随机抽取30例用于确定组织散射点模型的参数。其余15例用于后续仿真结果的定量统计比较分析。结果通过30例肾脏各参数进行超声仿真,用超声中心频率为5 MHz、换能器为128阵元的线性阵探头对超声射频回波信号经过包络提取、函数插值及对数压缩等处理得到仿真B超图像;同基于传统单一分布散射点模型的仿真结果相比,新方法仿真的肾脏肾髓质、肾皮质、孤立性肾囊肿及囊肿结缔组织回声与实际组织切片一致,也符合临床超声图像的表现。15例临床B超图像验证,仿真回声斑点的分布和各参数值与临床超声各参数一致性更好（P〈0.01）,最大相对误差为0.08,组织结构也更细致分明。结论混合分布构造散射点模型的孤立性囊肿肾脏超声仿真方法具有优越性,仿真效果更为逼真。
Objective To study and evaluate the ultrasonic simulation of solitary cyst kidney by speckle distribution mixed with 3 statistical models（Rayleigh, Rice and K distribution）. Methods A total of 45 patients with solitary cyst of kidney diagnosed by ultrasound scan were enrolled, included 20 males and 25 females, aged 30 - 75 years old with mean age of 51 years old. Thirty patients were chosen for determination of parameters in tissue scatter distribution models, and the rest for comparative analysis with simulated results. By clinical characteristics of tissue and distribution of echo speckle, the parameters for spatial distribution, density and intensity of tissue scatterer model（Rayleigh, Rice and K distribution） were obtained, and then simulated by FIELD Ⅱ software. Results The 30 cases of kidney were simulated with 5 MHz center frequency and 128 linear array transducer, then obtained the simulation B-mode images after envelope extraction, function interpolation and logarithmic compression. Compared with traditional sole scatterer model, the statistical distribution were consisted with actual tissue sections and performances of clinical ultrasound images in kidney of cortex, medulla, solitary cyst and cyst. Fifteen clinical B-mode connective tissue showed better consistency （P 〈 0.01） with the maximum relative error was 0.08, and provided clearly B -mode images in details of organizational structure. Conclusion It is demonstrated that the simulation for kidney with solitary cyst based on the scatterer model by mixed speckle distribution has superiority and better realistic effects.
出处
《生物医学工程与临床》
CAS
2016年第1期19-25,共7页
Biomedical Engineering and Clinical Medicine
基金
国家自然科学基金资助项目(61261007
61561049)
云南省自然科学基金重点项目(2013FA008)
关键词
超声仿真
混合斑点分布
肾脏
孤立性囊肿
FIELDⅡ
ultrasonic simulation
mixed speckle distribution
kidney cyst
kidney with solitary cyst
FIELD II
