摘要
目的:评价免疫抑制剂对急性百草枯中毒的疗效。方法:检索国内外1985年1月～2017年12月公开发表的免疫抑制剂治疗百草枯中毒的文献,筛选符合标准的文献,使用RevMan 5.3软件进行Meta分析。结果:根据纳入排除标准纳入5篇文献,Meta分析结果表明免疫抑制剂可以改善急性百草枯中毒患者的生存情况(RR=0.48,95%CI:0.28～0.84)。结论:本研究发现免疫抑制剂可以提高百草枯中毒的疗效。但目前文献存在明显异质性,证据尚不够充分,需要进行更多的临床随机对照试验以进一步明确。
Objective:To evaluate the efficacy of immunosuppressive therapy for acute paraquat poisoning.Methods:Relevant published articles concerned with immunosuppressive therapy for paraquat poisoning were searched at home and abroad during January 1980 to December 2017.The references were selected by inclusion and exclusion criteria and analyzed by the meta analysis software of RevMan 5.3.Results:5 studies were enrolled for meta analysis according to the inclusion and exclusion criteria.The results indicated that immunosuppressive therapy could improve the survival of paraquat poisoning(RR=0.48,95%CI:0.28 to0.84).Conclusion:This meta analysis suggests that immunosuppressive therapy can increase the efficacy of paraquat poisoning compared with conventional medical therapy.However,due to significant heterogeneity,a large randomized controlled trial is required to affirm the role of immunosuppressant in paraquat poisoning.
作者
张朝辉
廖海燕
雷超
Zhang Zhaohui;Liao Haiyan;Lei Chao(Department of Emergency and Intensive Care Unit,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;Institute of Evidence-Based and Translational Medicine,China Three Gorges University,Yichang 443003,China)
出处
《巴楚医学》
2018年第3期76-79,87,共5页
Bachu Medical Journal
基金
宜昌市科技局项目(No:LA15301-06)
三峡大学学位论文培优基金资助项目(No:2018SSPY108)
