摘要
目的探讨白癜风相关自身免疫性多腺体综合征(autoimmune polyglandular syndrome,APS)的临床特征及血清学特点。方法回顾性分析45例诊断为APS的白癜风患者的临床资料。结果 45例均有1种或多种甲状腺自身抗体阳性,分型均为APS-Ⅲ型;6例抗胃壁细胞抗体阳性,3例内因子抗体阳性,6例抗脱氨基麦胶蛋白抗体阳性,2例抗组织型谷氨酰氨转移酶抗体阳性,抗线粒体抗体及抗线粒体抗体亚型M2-3E、胰岛细胞抗体及谷氨酸脱羧酶抗体、SCL-70阳性各1例;诊断APS-ⅢA+C型和APS-ⅢC+D型各1例,APS-ⅢB+C型16例,APS-ⅢC型27例。结论白癜风可见于APS-Ⅲ型的所有亚型,临床应常规筛查甲状腺疾病,警惕其他相关自身免疫性疾病。
Objective To explore the clinical and serological characteristics in patients with autoimmune polyglandular syndrome （APS） associated with vitiligo. Methods The data of 45 patients with APS associated with vitiligo were retrospectively analyzed. Results One or more kinds of thyroid autoimmune antibodies were positive in all 45 patients and all patients were classified as APS-III. Autoantibodies against parietal cell antibody, intrinsic factor antibody, deamidated gliadin protein peptides and anti-tissue transglutamin were positive in 6, 3, 6 and 2 of 45 patients respectively. And anti-mitocbondrial antibody and isoforms of anti mitoehondrial antibody （M2-3E）, insular cellular antibody and glutamic acid decarboxylase antibody, and SCL-70 were positive in 1, 1 and 1 of 45 patients respectively. Classification analysis confirmed 1 patient with APS Ill A＋C, 1 patient with APS-IIIC＋ D, 16 patients with APS-III B＋C and 27 patients with APS-IIIC. Conclusion Vitiligo can be found in all subtypes of APS-III, therefore routine screening for autoimmune thyroid diseases should be performed and enough attention should be paid to other kinds of autoimmune disorders.
出处
《中华实用诊断与治疗杂志》
2016年第2期150-152,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省医学科技攻关计划项目(201402015)
