摘要
目的探讨高血压前期的患者血管紧张素Ⅱ2型受体自身抗体(抗AT2R)、尿清蛋白排泄率(UAER,mg/24h)、微量清蛋白尿阳性率(Malb)与血压水平的关系。方法选取在笔者医院接受检查226例患者作为研究对象,正常血压组、高血压前期组、高血压组。其中高血压前期组按照收缩压水平再分为高血压前期1组、高血压前期2组。采用酶联免疫法(ELISA)检测AT_2R、放射免疫检测(TNF-α)、内皮素1(ET-1)水平。并采用放射免疫法测定尿清蛋白排泄率(UAEmg/24h)、微量清蛋白尿阳性率(Malb%)。结果 3组接受检查者血浆抗AT_2R、TNF-α、ET-1之间差异有统计学意义(P<0.05);抗AT2R水平与收缩压、舒张压、平均动脉压呈负相关;3组尿清蛋白排泄率、微量清蛋白尿阳性率显著之间差异有统计学意义(P<0.05);高血压前期2组的尿清蛋白排泄率和微量清蛋白尿阳性率比1组更高。结论抗AT_2R受体随血压分组组别的升高而逐渐升高,并且与炎性因子肿瘤坏死因子、内皮素水平变化有关;高血压前期患者尿清蛋白排泄率的增加标志着高血压前期已经出现肾脏的损伤,肾脏损伤的严重程度随着高血压的发展逐渐增大,高血压前期患者可能已经出现了一些肾脏损害。
Objective To investigate the relationship between angiotensionⅡ receptor 2 autoantibody （AT2R antibody） and blood pressure in prehypertension patients, as well as the relationship of urinary albumin excretion rate （UAER, mg/24h） and urinary micro - albumin positive rate （Malb%） with blood pressure in prehypertension patients. Methods A total of 226 outpatients receiving examination in our hospital were selected as subjects, who were divided into normal blood pressure group （ ≤ 120/80mmHg, 51 patients） , prehypertension group （120- 139/80-89 mmHg, 121 patients） and hypertension group （≥ 140/90mmHg, 54 patients）. Patients in prehypertension group were divided into prehypertension group 1 （ 120 - 129 mmHg, 69 patients） and prehypertension group 2 （ 129 - 139 ram- Hg, 52 patients） according to systolic blood pressure. Peripheral AT2R antibody was detected using ELISA. Tumor necrosis factor- α （ TNF - α） and endothelin - 1 （ ET - 1 ） were detected using radioimmunoassay. UAER （mg/24h） and Malb% were detected using radioimmunoassay, and their difference was compared. Results There was significant difference in plasma AT2R antibody, TNF and endothelin among three groups （ P 〈 0.05 ）. AT2 R antibody was negatively correlated with systolic blood pressure, diastolic blood pressure and mean arterial pressure （r^2 = 0. 5870, 0. 8429 and 0. 9884, respectively）. There was significant difference in UAER and Malb% among three groups （P 〈 0.05）. Prehypertension group 2 had higher UAER and Malb% compared with group 1, but there was no significant difference （P 〉 0.05）. Conclusion AT2 R antibody gradually increases with the elevation of blood pressure, and its changes are related to the changes of inflammatory factors TNF and endothelin. Increased UAER in prehypertension patients represents that there has been renal damage in prehypertension and the severity of renal damage increases with the development of hypertension, which fully demonstrates that there ma
出处
《医学研究杂志》
2016年第1期155-158,共4页
Journal of Medical Research
