摘要
目的探讨眼内炎的常见病原菌及药物敏感率。方法选取眼内炎患者184例,取房水或者玻璃体接种于肉汤培养基、血琼脂培养基及马铃薯葡萄糖琼脂培养基行细菌和真菌培养,采用纸片扩散法进行药物敏感率分析。结果 184例患者中9例患者为混合感染,共培养获得致病菌193株。其中以革兰阳性菌感染最为常见,共检出108株,占55.96%,革兰阴性菌其次,检出63株,占32.64%,真菌检出较少,共22株,占11.40%。培养所得革兰阳性菌对头孢哌酮、头孢呋辛最为敏感,敏感率均达到87.96%,同时对左氧氟沙星、头孢唑林表现出了良好的敏感率,敏感率均达到75%以上,而对洛美沙星的敏感率较低,仅为50.00%。革兰阴性菌对洛美沙星的敏感率最高,达到100.00%,此外对环丙沙星和氧氟沙星的敏感率也分别达到87.30%和88.89%,而对头孢呋辛、头孢他啶及头孢唑啉的敏感率较低,分别仅为38.10%、39.68%和44.44%。结论根据眼内炎发生原因综合考虑病原菌感染种类,在发生眼内炎后经验用药期间可以选择联合给药。
Objective To investigate the common pathogens of endophthalmitis and their drug sensitivity. Methods 184 patients with endophthalmitis were selected. The aqueous humor or vitreous body was taken to inoculate in broth, blood agar and potato dextrose agar medium for conducting bacterial and fungal culture. The K-B method was adopted to conduct the drug sensitivity test. Results Among 184 cases,9 cases were the mixed infection and 193 strains of bacteria were co-cultured. Among them,gram positive bacteria infection was most common, 108 strains were detected, accounting for 55. 96%, followed by gram-negative bacteria, 63 strains were detected,accounting for 32.64% ,the detected fungi were less（22 strains） ,accounting for 11.40%. The cultured gram- positive bacteria were most sensitive to cefoperazone and cefuroxime both with the sensitivity of 87.96%, at the same time, levo floxacin and cefazolin showed good sensitivity,with the sensitivity of over 75%,while the sensitivity to lomefloxacin was low, only 50.00 %. Gram-negative bacteria had highest sensitivity to lomefloxacin, reaching 100.00%,in addition the sensitivity to ciprofloxa cin and ofloxacin also reached 87.30% and 88.89%, while the sensitivity to cefuroxime, ceftazidime and cefazolin was lower, which were only 38.10%,39. 68% and 44.44% respectively. Conclusion The infection types of pathogens should be comprehensively considered according to the causes of endophthalmitis occurrence. The combined medication should be selected during the empiric medication process after suffering from endophthalmitis.
出处
《国际检验医学杂志》
CAS
2016年第3期316-318,共3页
International Journal of Laboratory Medicine
关键词
眼内炎
病原学
药物敏感率
endophthalmitis
etiology
drug sensitivity
