摘要
目的:探讨度洛西汀联合认知治疗对慢性盆腔疼痛的临床疗效。方法:将120例慢性盆腔疼痛伴发抑郁和焦虑症状的患者随机分为认知治疗+度洛西汀组与度洛西汀组各60例,两组均口服度洛西汀治疗,研究组在此基础上联合认知心理治疗,观察6周。所有入组患者汉密尔顿焦虑量表(HAMA)评分≥14,汉密尔顿抑郁量表(HAMD)评分≥18分,度洛西汀组患者给予度洛西汀60 mg/d口服。治疗前、治疗后2、4、6周,两组患者分别进行HAMA和HAMD测评。结果:治疗6周末,两组HAMA、HAMD、数字疼痛评分(NRS)减分率分别达到68.32%、65.48%、55.93%以及53.75%、63.45%、39.82%,两组比较HAMA、NRS减分率差异有统计学意义(P<0.05)。结论:度洛西汀联合认知心理治疗能显著提高慢性盆腔疼痛伴发焦虑、抑郁、疼痛的临床疗效,更好改善焦虑、疼痛症状。
AIM: To observe the effect of duloxetine and cognitive therapy on women with chronic pelvic pain with anxiety and depression. METHODS: 120 patients from chronic pelvic pain withanxiety and depression were randomly divided into two groups( duloxetine group and mixed group combined duloxetine with cognitive therapy). Each group contained 60 cases and underwent 6-week ob-servation. All patients were administered with duloxetine,while patients in experimental group were given extra cognitive therapy. All patients ' scores of Hamilton Anxiety Scale( HAMA) were no less than14 and their scores of Hamilton Depression Scale( HAMD) were equal or greater than 18. Patients in duloxetine group were treated with duloxetine 60 mg per day. All patients were evaluated by HAMA and HAMD before treatment and the 2nd,4th,6th week after treatment. RESULTS: The reduction rates of HAMA,HAMD and NRS in cognitive therapy group were 53. 75%,63. 45%,39. 82%,respectively;while those in duloxetine group were 68. 32%,65. 48%,55. 93%,respectively. There were significant differences at reduction rates of HAMA and NRS between the two groups( P〈0. 05). CONCLUSION: Duloxetine mixed with cognitive therapy had more notable curative effect towards patients with chronic pelvic pain combined with anxiety and depression.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2015年第12期1418-1422,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
桐乡市课题(201403166)
关键词
慢性盆腔疼痛
焦虑
抑郁
度洛西汀
认知治疗
chronic pelvic pain
anxiety
depression
duloxetine
cognitive therapy