摘要
目的：观察逍遥散加减治疗原发性失眠的临床疗效。方法：采用临床随机对照试验方法,筛选符合纳入标准的失眠患者90例,其中试验组46例采用逍遥散加减治疗,对照组44例给予口服艾司唑仑治疗,4周1疗程,4周后随访。以匹兹堡睡眠质量指数（PSQI）为观察指标,采集并统计基线期、治疗后、随访期3个时点疗效相关数据,比较两种疗法的疗效差异。结果：治疗后试验组总有效率84.78%,对照组总有效率79.54%,两组总有效率无显著差异（χ~2=0.422,P=0.588〉0.05）;随访期试验组总有效率82.60%,对照组总有效率61.36%,两组总有效率有显著差异（χ~2=5.060,P=0.034〈0.05）。结论：逍遥散与艾司唑仑对原发性失眠均有较好的即时疗效,但逍遥散的远期疗效更优,更宜临床推广。
Objective： To observe the clinical effects of xiaoyao powder treatment for primary insomnia. Methods： The totally 90 patients with the primary insomnia are divided into 2 groups in a single-blind way randomly. The treatment group（ 46） chose the xiaoyao powder while the control group（ 44） chose the estazolan tablets. A course including 4 weeks and one month after the treatment there was a follow-up treatment. By taking Pittsburgh sleep quality index（ PSQI） as the observation target,collecting and summarizing the data of baseline period,after treatment period and follow-up period,we could get a statistical results of efficacy of the 2 kinds of treatments for the immediate and long-term clinical curative effects of primary insomnia. Results： The total effective rate of the after treatment period in treatment group was 84. 78 %,while the control group was 79. 54 %,which show that there was no significant difference between the two groups（ χ~2= 0. 422,P = 0. 588 〉 0. 05）. But the data of the follow-up period in treatment group was 82. 60 %,while the control group was 61. 36 %,which show that there’ s a significant difference between the 2 groups（ χ~2= 5. 060,P = 0. 034 〈 0. 05）. Conclusion： Xiaoyao powder and estazolan tablets are both have good instant curative effect in primary insomnia. But xiaoyao powder is superior to estazolan tablets on long-term curative effect and lasting effect,so it’ s more suitable for clinical promotion.
出处
《中国药物评价》
2015年第6期344-346,共3页
Chinese Journal of Drug Evaluation
关键词
逍遥散
原发性失眠
疗效观察
Xiaoyao powder
Primary insomnia
Clinical observation
