摘要
目的探讨孕晚期糖化血红蛋白（HbAlc）对妊娠期糖尿病（GDM）孕妇新生儿出生体重的影响。方法选取2014年1月至2015年2月在诸暨市妇幼保健院做产前检查及分娩的GDM孕妇101例（观察组），同时选取血糖正常的健康孕妇118例作为对照组，检测两组孕24～28周HbAlc水平，分析HbAlc与新生儿出生体重的关系。结果观察组孕24～28周HbAlc为（7．84±1．54）％。明显高于对照组的（5．63±1．39）％，t=11．209，P〈0．05，观察组新生儿出生体重为（3．94±0．78）kg，明显高于对照组的（3．25±0．64）kg，差异有统计学意义（P〈0．05）；观察组孕24～28周HbAlC与新生儿出生体重呈正相关（r=0．757，P〈0．001），而对照组孕24～28周HbAlc与新生儿出生体重无相关性（P〉0．05）；观察组孕24～28周HbAlc诊断巨大儿的ROC曲线下面积为0．924，P〈0．001，截断值为7．59％时，灵敏度为96．90％，特异度为80．00％。结论GDM孕妇HbAlc对估计新生儿出生体重具有一定的预测价值。
Objective To investigate the influence of glycosylated hemoglobin （HbAlc） at late pregnancy on birth weight of neonates of pregnant women with gestational diabetes mellitus （GDM）. Methods From January 2014 to February 2015 101 pregnant women with GDM accepting prenatal examination and giving birth in Zhuji City Maternal and Child Health Hospital were selected in observation group, and 118 heahhy pregnant women with normal blood glucose were selected as controls. HbAlc levels at 24 - 28 weeks of pregnancy of two groups were detected, and the relationship between HbAI c and birth weight of newborns was analyzed. Results HbA1 c of the observation group at 20 -28 weeks of pregnancy was 7.84±1.54% , which was significantly higher than that （5.63 ± 1.39% ） of the control group （ t = 11. 209 ,P 〈 0. 05）. The neonatal birth weight of the observation group was 3.94 ± 0.78kg, which was remarkably higher than that （3.25 ＋ 0.64kg） of the control group with significant difference （P 〈0. 05）. In the observation group HbAlc at 24 - 28 weeks of pregnancy was positively correlated with neonatal birth weight （ r = 0. 757, P 〈0. 001 ）, while it was not correlated with neonatal birth weight in the control group （P 〉 0.05）. Area under ROC curve of HbA1 c in diagnosing macrosomia at 24 -28 gestational weeks in the observation group was 0. 924 （ P 〈 0. 001 ）, and the sensitivity and specificity was 96.90% and 80. 00%, respectively when cutoff value was 7. 59%. Conclusion HbAlc of cases with GDM can be used to estimate neonatal birth weight.
出处
《中国妇幼健康研究》
2015年第6期1228-1230,共3页
Chinese Journal of Woman and Child Health Research
关键词
妊娠期糖尿病
孕晚期
糖化血红蛋白
新生儿体重
gestational diabetes mellitus （GDM）
late pregnancy
HbAlc
neonatal weight
