摘要
关节软骨位于骨骼末端,主要起承重、减震和润滑关节的作用。由于缺乏血运,关节软骨损伤后难以自行修复。关节软骨损伤为临床常见疾病,目前尚无理想的方法促进其修复和再生,而以种子细胞、支架材料和细胞生长因子为基础的组织工程技术为关节软骨修复开辟了新道路。诱导多能干细胞(i PSC)作为软骨组织工程全新的种子细胞,与其他种子细胞相比,在软骨细胞移植及体外软骨组织和器官再造方面具有更广阔的应用前景。随着对i PSC的重编程机制、诱导方法、定向软骨分化条件以及临床应用安全性等研究的不断深入,其应用于临床的脚步将越来越近。
Locating at the ends of bone, articular cartilage provides weight bearing, shock absorption and lubrication to the diarthrodial joints. Articular cartilage has no blood vessels, and thus has poor self-repairing capacity after being damaged. Articular cartilage injury is common in clinical settings and there are no ideal treatments which can effectively improve the cartilage regeneration. Recently, the emergence and development of tissue engineering technology based on seed cells, scaffolds and growth factor provides a new approach for the repair of articular cartilage injury. Induced pluripotent stem cell （iPSC） , a new kind of seed cell for cartilage tissue engineering, shows overwhelming advantages for chondrocyte, cartilage tissue or organ regeneration over the other seed cells. With the rapid development of tissue engineering technology and breakthroughs made in iPSC research field, such as a better understanding of cellular reprogramming mechanism, the optimization of the methods for chondrogenic differentiation, the iPSC and tissue engineering technology will be used for articular cartilage injury in the foreseeable future.
出处
《中华细胞与干细胞杂志（电子版）》
2015年第4期57-62,共6页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
吉林省卫生计生科研计划(20142037)
关键词
多能干细胞
关节
软骨
组织工程
Multipotent stem cells
joints cartilage
tissue engineering
