摘要
目前,经皮冠状动脉介入(PCI)作为治疗冠心病的首选治疗,挽救了患者生命,改善了生活质量。但是PCI术对血管内皮的损伤,进而血栓形成,诱导内皮祖细胞和平滑肌细胞的增殖、迁移、基质重塑以及炎症反应的发生等,容易造成PCI术后再狭窄的发生。虽然目前临床上,术后常规使用抗血小板药物以及药物洗脱支架的出现在一定程度上降低再狭窄的发生率,但PCI术后再狭窄的发生率仍较高。因此,探讨PCI术后再狭窄的机制,以及相应干预方法,对于减少术后再狭窄的发生具有重要作用。
With the increasing incidence of coronary heart disease gradually,the application of percutaneous coronary intervention （PCI） are increasingly common, and PCI can significantly save the lives of patients, improve the quality of life of patients, but may be followed with restenosis because PCI caused endovascular injury may further develop into thrombosis, induce proliferation, migration of endothelial progenitor cells and smooth muscle cells, matrix remodeling and inflammation etc. Although some ways can reduce the incidence of restenosis to some extent, like postoperative antiplatelet drugs, drug-eluting stents, the incidence of restenosis after PCI is still relatively high. Therefore, it is necessary to clarify the mechanisms and counter- measures of vascular injury and restenosis after PCI to reduce the incidence of restennsis.
出处
《医学综述》
2016年第2期280-283,共4页
Medical Recapitulate
基金
广西科学研究与技术开发计划项目桂科攻(1140003A-50)
关键词
冠心病
经皮冠状动脉介入术
再狭窄
机制
Coronary heart disease
Percutaneous coronary intervention
Restenosis
Mechanisms
