期刊文献+

阿尔茨海默病生物标志物的研究进展 被引量:5

Research Progress in Biological Markers for Alzheimer Disease
下载PDF
导出
摘要 前人关于阿尔茨海默病已进行了大量的研究。近年来,阿尔茨海默病的发病率正逐年攀升,其病理改变出现早,家属识别率、就诊率低,目前临床确诊仍主要依靠症状学诊断,故寻找一种可用于早期阿尔茨海默病诊断的生物学标志物便显得尤为重要。时下有关阿尔茨海默病的生物学标志物已逐渐成为研究的热点,在阿尔茨海默病的诊断中可能具有广阔的前景。 There have been amount of research on Alzheimer disease. Recently, The morbidity of Alzheimer disease is increasing year by year, since he pathological changes appear earlier than clinical symptoms,it has a poor recognition rate and consultation rate. The current clinical diagnosis is still mainly relying on symptoms, so it is particularly important to find out some biological markers for early diagnosis of Alzheimer disease. The biological markers for Alzheimer disease have gradually become a research hotspot, which may have broad prospects in the diagnosis of Alzheimer disease.
出处 《医学综述》 2016年第2期227-230,共4页 Medical Recapitulate
基金 青岛市医药科研指导计划(2008-wszd111)
关键词 阿尔茨海默病 Β-淀粉样蛋白 TAU蛋白 同型半胱氨酸 阿尔茨海默病相关神经丝蛋白 Alzheimer disease 13-amyloid protein Tau protein Homocysteine Alzheimer-associated neurofilament protein
  • 相关文献

参考文献30

  • 1Querfurth HW,La Ferla FM.Alzheimer's disease[J].N Engl J Med,2010,362(4):329-344. 被引量:1
  • 2Lee TS,Krishnan KR.Alzheimer's disease-the inexorable epidemic[J].Ann Acad Med Singapore,2010,39(7):505-506. 被引量:1
  • 3田燕,卢瑞春,郁金泰,谭兰.CR1基因多态性与汉族人迟发性阿尔茨海默病关系[J].齐鲁医学杂志,2012,27(1):25-27. 被引量:3
  • 4Saido TC.Metabolism of amyloidβpeptide and pathogenesis of Alzheimer's disease[J].Proc Jpn Acad Ser B Phys Biol Sci,2013,89(7):321-339. 被引量:1
  • 5庄莹,陈杰.阿尔茨海默病病因及发病机制研究进展[J].吉林医药学院学报,2008,29(2):101-104. 被引量:23
  • 6Britschgi M,Rufibach K,Huang SL,et al.Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome[J].Mol Cell Proteomics,2011,10(10):M111.008862. 被引量:1
  • 7Consensus report of the Working Group on:"Molecular and Biochemical Markers of Alzheimer's Disease".The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group[J].Neurobiol Aging,1998,19(2):109-116. 被引量:1
  • 8Noguchi M,Yoshita M,Matsumoto Y,et al.Decreased beta-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration[J].J Neurol Sci,2005,237(1/2):61-65. 被引量:1
  • 9Blennow K,Hampel H.CSF markers for incipient Alzheimer's disease[J].Lancet Neurol,2003,2(10):605-613. 被引量:1
  • 10Lewczuk P,Kornhuber J,Vanmechelen E,et al.Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease:A multicenter study with multiplexing[J].Exp Neurol,2010,223(2):366-370. 被引量:1

二级参考文献78

共引文献48

同被引文献41

引证文献5

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部