摘要
目的探讨辅助性T细胞(Th1)水平与鼻咽癌患者的预后的相关性以及鼻咽癌患者预后的危险因素。方法选取我院2007年1月至2009年12月期间收治的124例诊断为鼻咽癌的患者,对其预后的危险因素进行回归分析,同时对患者的Th1细胞水平与鼻咽癌患者的预后的相关性进行分析。结果 124例患者中1年生存率为85.5%,3年生存率为70.2%,5年生存率为59.7%;患者的白细胞介素(IL)-2的水平随着生存时间的增加而升高,而肿瘤坏死因子(TNF)-α随着生存时间的增加而降低,差异均具有统计学意义(P<0.05),而不同生存时间的患者其干扰素(IFN)-γ比较差异无统计学意义(P>0.05);临床分期、T分期及N分期对鼻咽癌患者的生存率差异存在统计学意义(P<0.05),而患者的年龄、T分期、N分期以及治疗方式是影响鼻咽癌患者预后的独立相关危险因素。结论 Th1细胞因子中IL-2及TNF-α的水平能够作为鼻咽癌患者预后判断的生物学指标,同时患者的年龄越大、分期越高其预后越差,并且综合治疗的效果要高于单独放疗治疗。
Objective To investigate the correlation of nasopharyngeal carcinoma with Thl cellular level and the outcome and risk factors for the patients. Methods One hundred twenty-four cases of nasopharyngeal carcinoma patients were selected from our hospital between January 2007 and December 2009. The regression analysis of risk factors of prognosis was carried out and the correlation of Thl cellular level with nasopharyngeal carcinoma was studied. Results In the 124 cases, the survival rate was 85.5% in one year, 70.2% in 3 years and 59.7% in 5 years; the level of IL-2 in patients increased with the time, but the IFN gamma-reduced with the time. The difference was statistically significant （ P 〈0.05）. There was no statistical significance in the level of IFN -gamma of different times. The survival rate of patients was of statistical difference in clinical stages, T stages and N stages. The independent risk factors that affect the patients with nasopharyngeal carcinoma were age, T stages, N stages and therapy method. Conclusion The level of IL-2 and TNF-αlpha in Thl cytokines could be acted as the biological index for the prognosis of patients with nasopharyngeal carcinoma. The prognosis was worse with the increasing age of patients and more malignant stage. And the effect of comprehensive treatment was better than that of radiation therapy.
出处
《山西医药杂志》
CAS
2016年第2期137-140,共4页
Shanxi Medical Journal
关键词
鼻咽肿瘤
预后
TH1细胞
危险因素
Nasopharyngeal neoplasms
Prognosis
Thl cells
Risk factors
