摘要
目的研究成人急性阑尾炎与家族遗传因素的关系。方法选择本院收治的126例成人急性阑尾炎患者为观察组,另选择同期120例健康者为对照组。综合整理两组研究对象的临床资料,调查急性阑尾炎患者家族遗传史、临床症状、阑尾炎病理类型、病原菌类型及实验室指标(包括C反应蛋白、白细胞计数及中性粒细胞百分比)。统计两组研究对象急性阑尾炎家族遗传史的阳性率,并对比分析观察组有家族遗传史患者和无家族遗传史患者的病理特征。结果观察组患者中急性阑尾炎家族遗传史阳性率为31.75%,对照组为11.67%,两组比较差异具有显著性(P<0.05)。观察组中有家族遗传史患者的平均年龄小于无家族遗传史患者(P<0.05);有家族遗传史患者发热、腹膜刺激征、化脓性阑尾炎及坏疽性阑尾炎的发生率高于无家族遗传史患者(P<0.05);有家族遗传史患者的平均C反应蛋白、白细胞计数、中性粒细胞百分比均高于无家族遗传史患者(P<0.05)。结论家族遗传因素在成人急性阑尾炎发病中具有重要作用,且可能是影响急性阑尾炎患者发病年龄、临床症状、病理类型及病情的重要因素。
Objective To study the relationship between adult acute appendicitis and familial genetic factors. Method 126 cases of acute appendicitis patients in our hospital were selected as observation group, and 120 cases of healthy people were selected as control group. The clinical data of the two groups were collected to investigate the genetic history, clinical symptoms, pathological types, pathogenic bacteria types and laboratory indexes（including CPR, WBC and the percentage of neutrophils）. Result Prevalence rate of observation group and conrol group were 31.75% and 11.67% respectively, there was significant differences between the two groups（P〈0.05）. In observation group, the average age of the patients with family history was smaller than that in patients without family history（P〈0.05）. The incidence of fever, peritoneal irritation sign, suppurative appendicitis and gangrenous appendicitis in patients with family history was higher than that in patients without family history（P〈0.05）. The average CRP, WBC and neutrophil percentage were higher in the patients with family history than those without family history（P〈0.05）. Conclusion Family genetic factors play an important role in the pathogenesis of adult acute appendicitis, and may be an important factor affecting the pthogenesis age, clinical symptoms, pathological types and disease of acute appendicitis.
出处
《中国医学前沿杂志（电子版）》
2015年第11期89-92,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
急性阑尾炎
成人
家族遗传
Acute appendicitis
Adult
Family heredity
