摘要
目的观察高频稳态噪声对雌性大鼠脑、心脏、肝脏以及脾脏组织的病理影响。方法将20只SD雌性大鼠随机分为噪声暴露组与对照组,每组10只,噪声暴露组大鼠持续暴露高频稳态噪声2 w,取两组大鼠的脑、心脏、肝脏及脾脏组织进行病理组织切片并镜下观察各脏器组织有无病理改变。结果噪声暴露组高频噪声暴露值明显高于对照组,两组比较差异有统计学意义(P<0.01)。持续暴露高频稳态噪声2 w后,和对照组相比,噪声暴露组光镜下脑组织结构疏松紊乱、充血、水肿,血管扩张,神经胶质细胞增生,区域伴轻度异型(核深染,核型不规则);未见变性和坏死。肝脏组织中央静脉、肝窦、小叶间静脉扩张淤血,肝小叶结构破坏,较多炎症细胞浸润,淋巴小结形成。脾脏结构尚存,有淤血,脾窦高度扩张淤血,白髓淋巴组织增生活跃;心脏心肌间质血管扩张淤血,心肌细胞轻度变性、充血,未见出血及心肌细胞坏死。结论高频稳态噪声能引起雌性大鼠脑、心脏、肝脏及脾脏组织不同程度的病理损伤。
Objective To investigate the pathological damage of high-frequency stable noise exposure on the brain,heart,liver,and spleen of female rats. Methods 20 female SD rats were randomly divided into experimental and control groups with 10 rats in each group. Rats in the experimental group were exposed to continuous high-frequency stable noise for two weeks（ three hours / day）,and then the pathological damages in rat＇s brain,heart,liver and spleen were compared to those of the control group. Results After two weeks＇ continuous exposure to highfrequency stable noise,compared with control group,the most prominent histopathologic changes in the brain tissue structures of the experimental group included loose disorder,hyperemia,edema,blood vessels expand,glial cell hyperplasia,mild atypia in some areas（ hyperchromatic nuclei,irregular karyotype）,and no degeneration and necrosis. There were dilatation and congestion of central vein,hepatic sinus and interlobular veins of liver tissue.The structure of hepatic lobule was destroyed by inflammatory cell infiltration,as well as lymphoid nodule formation. There was hyperemia in spleen,but the structure was clear. There was extravasated blood,and the splenic sinuses were highly expanded by blood clot. Hyperplasias of the lymphoid of white pulp were also active. There was dilation and congestion in myocardial interstitial vascular,and there was mild degeneration and hyperemia in myocardial cells. No hemorrhage and myocardial necrosis were observed. Conclusion High-frequency stable noise can cause pathological damage in brain,liver,spleen and heart tissues of female rat at a various degree.
出处
《新疆医科大学学报》
CAS
2016年第2期200-202,206,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区克拉玛依市科技基金项目(SK2011-46)
关键词
高频稳态噪声
组织病理
雌性大鼠
high-frequency stable noise
histopathologic
female rats
