摘要
扩散波光谱学(DWS)是由动态光散射技术发展而来的,该技术是将一束多重光射入含有分散相的物质中,光子经过不同的路程被散射回来,产生干涉,光谱信号表现为明暗相间的光斑,光斑的变换速度体现了物质中粒子的运动速度。DWS技术较多应用于研究高度浑浊不透明介质粒子的大小、结构及其之间的相互作用。近年来DWS技术主要应用在化工业中乳液成膜过程的分析和乳胶粒子成膜过程的作用机制研究,食品工业中食品凝胶的粘弹性、乳剂性食品中不同牛奶的稳定性测定、非乳剂性食品的微观流变学性质的表征,在医药中应用的文献报道较少,医药中主要用于表征血管中血液流量和血液的微循环情况、悬浮聚合物的粒度分析等。通过综述DWS技术的原理,在乳液成膜过程、食品凝胶、乳剂性食品和医药中的应用情况,展望其在医药研究方面的发展前景,为DWS技术在药物制剂研究方面的应用提供借鉴。
Diffusing wave spectroscopy（DWS） is a kind of dynamic light scattering technology,it is a technology which lets multi-light beam into materials containing dispersed phase, and then photons through different distances are scattered and leads to interference,spectrum signal shows white light spot,transforming speed of spot reflects velocity of material particles. DWS technology applied in the high turbidity not more transparent medium particle size,structure and their interactions. In recent years,DWS technology is mainly used in chemical industry（emulsion film forming process analysis and mechanism research of latex particle filmforming process） and food industry（gel viscoelastic,stability determination of different milk in emulsion foods and rheological properties characterization of non-emulsion food）,but application in medical literature reported less,it is mainly used for characterization of vascular blood flow and blood microcirculation, particle size analysis of suspension polymer in medicine. By investigating principle and application of DWS,this paper will prospect its development in medicine.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第2期216-221,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江西省自然科学基金项目(20122BAB205071)
江西民族传统药现代科技与产业发展协同创新中心2014年度协同创新项目(JXXT201403015)
江西省研究生创新专项(YC2014-S290)
关键词
扩散波光谱学
粒子运动
动态光散射技术
中成药
diffusion wave spectroscopy
particle motion
dynamic light scattering technology
Chinese patent medicine
