摘要
剂量-反应Meta分析中,探讨自变量与因变量之间的因果关系通常的做法是建立回归模型。经典的模型中需同时考虑线性及非线性趋势。传统的线性模型是基于一次函数的简单模型,而这种模型适用性较差。本文在线性模型基础上,通过引入分段函数,建立分段线性剂量-反应Meta分析模型,很好地弥补了传统线性模型的不足。本文将详细探讨剂量-反应Meta分析中线性及分段线性模型的方法学及应用。
When investing the relationship between independent and dependent variables in dose-response meta- analysis, the common method is to fit a regression function. A well-established model should take both linear and non- linear relationship into consideration. Traditional linear dose-response meta-analysis model showed poor applicability since it was based on simple linear function. We introduced a piecewise linear function into dose-response meta-analysis model which overcame this problem. In this paper, we will give a detailed discussion on traditional linear and piecewise linear regression model in dose-response meta-analysis.
出处
《中国循证医学杂志》
CSCD
2016年第1期111-114,共4页
Chinese Journal of Evidence-based Medicine
关键词
剂量-反应关系
线性预测
分段线性函数
META分析
Dose-response relationship
Linear prediction
Piecewise linear regression
Meta-analysis
