摘要
目的探讨血必净联合前列地尔治疗慢性阻塞性肺疾病(COPD)并发多器官功能障碍综合征(MODS)的疗效。方法选取2011年5月至2014年9月在河北省民政总医院接受治疗的COPD并发MODS患者120例为研究对象,依据随机数字表法分为对照组和观察组,各60例。对照组采用传统的常规治疗,观察组在传统治疗模式的基础上采用血必净联合前列地尔治疗(每日静脉滴注血必净100 m L,每日2次,前列地尔10μg加入生理盐水10 m L,连续静脉注射14 d)。观察比较两组患者治疗前后的MODS情况、肺动脉压、动脉血二氧化碳分压、动脉血氧分压以及临床治疗有效率。结果治疗后观察组各项脏器衰竭发生率低于对照组,差异有统计学意义(P<0.05)。治疗后观察组和对照组的肺动脉压分别为(20±5)mm Hg(1 mm Hg=0.133 k Pa)和(32±6)mm Hg,动脉血二氧化碳分压分别为(512±6)mm Hg和(58±6)mm Hg,动脉血氧分压分别为(66±7)mm Hg和(55±7)mm Hg,观察组优于对照组(P<0.01);治疗后观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。结论采用血必净联合前列地尔治疗可促进COPD并发MODS患者病情好转,降低病死率。
Objective To research the efficacy of xuebijing combined alprostadil on patients with chronic obstructive pulmonary disease（ COPD） complicated with multiple organ dysfunction syndrome（ MODS）. Methods Total of 120 cases of COPD complicated with MODS admitted to Hebei Civil Affairs General Hospital from May. 2011 to Sep. 2014 were included in the study,and randomly divided into observation group and control group according to random number table method,60 cases in each group. Conventional treatment was given to patients in the control group,while xuebijing combined alprostadil was given to the observation group（ daily intravenous infusion of xuebijing 100 mL,2 times a day,alprostadil of 10 μg added into 10 mL physiological saline for intravenous injection for 14 days） on the basis of the control group＇s treatment. The situation of MODS,the pulmonary artery pressure,CO2 partial pressure,O2 partial pressure and clinical efficacy were compared between the two groups. Results After treatment,the organ failure incidence of the observation group was lower than the control group（ P〈0. 05）. After treatment,the pulmonary artery pressure of the observation group and the control group were（ 20 ± 5） mmHg and（ 32 ± 6） mmHg,CO2 partial pressure were（ 52 ± 6） mmHg and（ 58 ± 6） mmHg,O2 partial pressure were（ 66 ± 7） mmHg and（ 55 ± 7） mmHg respectively,the observation group was superior to the control group（ P〈0. 05）; the clinical efficacy of the observation group was better than the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Using xuebijing combined alprostadil to treat patients of COPD complicated with MODS has a positive effect on the disease condition and reduce the mortality.
出处
《医学综述》
2016年第1期184-185,188,共3页
Medical Recapitulate
关键词
慢性阻塞性肺疾病
多器官功能障碍综合征
血必净
前列地尔
Chronic obstructive pulmonary disease
Multiple organ dysfunction syndrome
Xuebijing
Alprostadil
