摘要
目的观察地佐辛超前镇痛对小儿七氟烷全身麻醉扁桃体切除术后苏醒期躁动的防治效果。方法择期在七氟烷全身麻醉下行扁桃体切除术的患儿60例,按随机数字表法分为地佐辛组和对照组各30例。地佐辛组于麻醉诱导前5 min给予静脉注射地佐辛0.1 mg/kg,对照组给予等量生理盐水,其余麻醉方法两组相同。记录拔管后0、1、2、4、8 h的平均动脉压(MAP)、心率、儿童麻醉后躁动(PAED)评分及拔管后1、2、4、8 h的疼痛视觉模拟(VAS)评分;记录停药至拔管时间及麻醉后监测治疗室(PACU)滞留时间;对比两组术毕至术后6 h内发生呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应的发生率。结果地佐辛组拔管后0、1、2、4、8 h的MAP、心率、PAED及拔管后1、2、4、8 h的VAS评分均明显低于对照组(P<0.05);地佐辛组PACU滞留时间、停药至拔管的时间均略长于对照组,不良反应发生率稍高于对照组,但差异均无统计学意义(P均>0.05)。结论采用地佐辛0.1 mg/kg行超前镇痛对小儿七氟烷全身麻醉扁桃体切除术后苏醒期躁动有很好的抑制作用,能提高麻醉复苏质量。
Objective To observe the prevention and treatment effects of preemptive analgesia with dezocine on children with emergence agitation following tonsillectomy with sevoflurane general anesthesia. Methods Sixty children underwent elective tonsillectomy with sevoflurane general anesthesia were divided into dezocine group and control group by random number table,with 30 cases in each group. The two groups accepted the same anesthesia methods besides that dezocine group was given intravenous dezocine of 0. 1 mg / kg while control group was given the same amount of normal saline five minutes before anesthetic induction. Mean arterial pressure（ MAP）,heart rate and pediatric anesthesia emergence delirium（ PAED） score were recorded 0,1,2,4 and 8 hours after extubation. Visual Analogue Scale（ VAS） scores 1,2,4 and 8 hours after extubation as well as the duration from drug withdrawal to extubation and post-anesthesia care unit（ PACU） stay were also recorded. The incidences of adverse reactions such as respiratory depression,nausea and vomiting,itchy skin which occurred from the end of operation to the 6th hour after operation were compared between two groups. Results Dezocine group had significantly lower MAP,heart rate and PAED 0,1,2,4 and 8 hours after extubation as well as significantly lower VAS scores 1,2,4 and 8hours after extubation compared to control group（ P 〈 0. 05）. PACU stay and the duration from drug withdrawal to extubation in the dezocine group were slightly longer than those in the control group,the incidence of adverse reactions in the dezocine group was slightly higher than that in the control group,but there was no statistically significant difference（ all P 〉 0. 05）. Conclusion Preemptive analgesia with dezocine of 0. 1 mg / kg has favorable inhibitory effects on children with emergence agitation following tonsillectomy with sevoflurane general anesthesia,and can improve the quality of anesthesia recovery.
出处
《广西医学》
CAS
2015年第11期1587-1590,共4页
Guangxi Medical Journal
关键词
扁桃体切除术
地佐辛
超前镇痛
小儿
七氟烷
全身麻醉
躁动
苏醒期
Tonsillectomy
Dezocine
Preemptive analgesia
Children
Sevoflurane
General anesthesia
Agitation
Recovery period
