摘要
目的了解大动脉粥样硬化狭窄性脑梗死与小动脉闭塞性脑梗死危险因素有无不同。方法从河北任丘康济医院神经内科自2014年建立的缺血性卒中急性期干预、二级预防登记研究数据库中根据入组标准抽取了符合标准的736例脑梗死患者。根据有无大动脉狭窄将患者分为2组：狭窄组303例,平均年龄（64.41±10.9）岁;非狭窄组433例,平均年龄（61.88±11.08）岁。分析大动脉粥样硬化狭窄性脑梗死与小动脉闭塞性脑梗死危险因素有无不同。结果单因素分析年龄、空腹血糖、糖尿病、高密度脂蛋白与大动脉粥样硬化狭窄性脑梗死有关,有统计学意义。以大动脉粥样硬化狭窄性脑梗死为应变量,将单因素分析有意义的自变量进行多因素Logistic回归分析,在校正了空腹血糖等因素后,显示年龄（校正OR=1.024;95%CI=1.010～1.039;P〈0.05）、糖尿病（校正OR=1.572;95%CI=1.113～2.219;P〈0.05）是大动脉粥样硬化狭窄性脑梗死相关的独立危险因素。而高密度脂蛋白胆固醇（校正OR=0.650;95%CI=0.432～0.977;P〈0.05）是大动脉粥样硬化狭窄性脑梗死的保护因素。结论大动脉粥样硬化狭窄性脑梗死与小动脉闭塞性脑梗死危险因素有所不同,糖尿病、年龄是大动脉粥样硬化狭窄性脑梗死的独立危险因素,而高密度脂蛋白胆固醇是大动脉粥样硬化狭窄性脑梗死的保护因素。
Objective To investigate the risk factors between ischemic cerebral infarction in large-artery atherosclerotic stenosis and small artery occlusive cerebral infarction.Methods The subjects were based on the standard extract of 736 patients with cerebral infarction.According to the presence of artery stenosis,the patients were divided into two g roups：stenosis group（303cases）,non-stenosis group（433cases）.The risk factors between ischemic cerebral infarction with large-artery atherosclerotic stenosis and small artery occlusive cerebral infarction were analyzed.Results After adjusting potential confounders,age（adjusted OR =1.024;95% CI =1.010-1.039;P 〈0.01）,diabetes（adjusted OR =1.572;95%CI =1.113-2.219;P =0.010）were shown to be significant associates in schemic cerebral infarction with large-artery atherosclerotic stenosis.High density lipoprotein cholesterol（adjusted OR =0.650;95% CI = 0.432-0.977;P 〈0.05） was the protection factor of ischemic cerebral infarction in large-artery atherosclerotic stenosis.Conclusion Age,diabetes are independent risk factors for ischemic cerebral infarction in largeartery atherosclerotic stenosis.High density lipoprotein cholesterol is the protection factor.
出处
《临床荟萃》
CAS
2016年第1期77-80,共4页
Clinical Focus
关键词
梗塞
大脑中动脉
脑梗死
危险因素
infarction
middle cerebral artery
brain infarction
risk factors
