摘要
目的研究抗生素应用在感染后咳嗽（post-infectious cough,PIC）治疗过程中的临床效果,为感染后咳嗽的合理用药提供一定的依据。方法将杭州市下城区长庆潮鸣街道社区卫生服务中心2013年7月至2014年7月全科门诊诊治的气道激发试验阴性的感染后咳嗽患者104例随机分为A、B、C三组。A组（35例）采用阿奇霉素治疗,B组（35例）采用复方甲氧那明治疗,C组（34例）采用以上两种药物联合使用治疗方案,疗程均为1周,观察治疗前后各组间患者咳嗽症状的改变情况。结果治疗后三组患者的咳嗽积分均低于治疗前（t=13.795、12.224、17.219,P〈0.05）,咳嗽症状有所好转,治疗后三组咳嗽积分比较差异具有统计学意义（F=4.58,P〈0.05）,C组治疗后咳嗽积分显著性低于A、B两组（t=3.652、4.345,P〈0.05）,A、B两组相比差异无统计学意义（t=1.095,P〉0.05）;C组经治疗后有效率（94.1%）均高于A组（74.3%）和B组（74.3%）（χ^2=10.617、11.968,P〈0.05）,A组和B组间未见明显差异（χ^2=0.130,P〉0.05）。结论对于气道激发试验阴性的感染后咳嗽使用抗生素具有一定的治疗效果。
Objective To investigate the clinical effect of antibiotics in treating post-infectious cough（PIC）,and provide direction for clinical treatment of PIC.Methods One hundred and four PIC outpatients who were admitted into our hospital and had negative response to bronchial provocation test were randomly divided into group A（35cases,treated with azithromycin）,group,B（35cases,treated with Methoxyphenamine[CM]）,or group C（34cases,treated with Azithromycin and CM）respectively.The treatment course was one week.The therapeutic effects were evaluated by scores among the three groups.Results The cough scores of all groups after treatment were lower than before（t=13.795,12.224,17.219,P〈0.05）,The cough scores of three groups after treatment had significant difference（F=4.58,P〈0.05）.The cough scores of group C after treatment was significantly lower than that of group A and group B（t=3.652,4.345,P〈0.05）,A,B two groups had no significant difference（t=1.095,P〉0.05）.Ssuggesting improvement of the cough symptoms.The efficiency rate in group C was higher than that in groups A and B after treatment（χ^2=10.617,11.968,P〈0.05）,while no significant difference was observed between groups A and B（χ^2=0.130,P〉0.05）.Conclusion Antibiotics have a certain therapeutic effect in PIC patients with negative response to bronchial provocation test.
出处
《中国微生态学杂志》
CAS
CSCD
2016年第1期68-71,共4页
Chinese Journal of Microecology
关键词
感染后咳嗽
气道反应性
抗生素
Post-infectious cough
Airway responsiveness
Antibiotics
