摘要
背景2型糖尿病(T2DM)患者存在认知损伤,近来研究显示抑郁与认知损伤相关。目的探讨T2DM患者抑郁情绪对认知功能的影响。方法收集2013年4月—2014年10月在唐山工人医院内分泌科住院的T2DM患者264例。对其应用Zung抑郁自评量表(SDS)评定抑郁情绪,其中SDS标准分≥53分者作为A组(n=68),SDS标准分<53分者作为B组(n=196)。对两组患者应用可重复成套神经心理状态测验(RBANS)进行认知功能评定,记录即刻记忆、视觉空间、语言能力、注意能力和延迟记忆评分,分析影响T2DM患者认知的因素。结果 264例T2DM患者中,68例存在抑郁情绪,抑郁患病率为25.8%。两组视觉空间、语言能力、注意能力评分比较,差异均无统计学意义(P>0.05);A组即刻记忆、延迟记忆及RBANS标准分均低于B组,差异有统计学意义(P<0.05)。进行协方差分析后,A组延迟记忆评分低于B组,差异有统计学意义(F=5.1,P<0.05)。Pearson相关分析结果显示,T2DM患者SDS标准分与即刻记忆(r=-0.14,P<0.05)、延迟记忆(r=-0.21,P<0.05)及RBANS标准分(r=-0.13,P<0.05)呈直线负相关。多元线性回归分析结果显示,SDS标准分是影响T2DM患者延迟记忆的因素(b=-0.22,β=-0.21,t=-3.00,P<0.05)。结论抑郁情绪会加重T2DM患者认知损伤。
Background Cognitive injury usually exists in patients with type 2 diabetes mellitus（ T2DM）,and the recent researches have shown that depression is correlated with cognitive injury. Objective To investigate the influence of depression on the cognitive function of T2 DM patients. Methods We enrolled 264 T2 DM patients who were admitted into the Department of Endocrine of Tangshan Gongren Hospital from April 2013 to October 2014. The depression of the subjects was evaluated by Zung self-rating depression scale（ SDS）. The subjects with SDS standard score≥53 were assigned into group A（ n = 68） and the subjects with SDS standard score 53 were assigned into group B（ n = 196）. Repeatable Battery for the Assessment of Neuropsychological Status（ RBANS） were adopted to assess the cognitive function of the subjects,by which the scores of immediate memory,visuospatial,language,attention and delayed memory were recorded,and the influencing factors for the cognition of T2 DM patients were analyzed. Results Among the 264 T2 DM patients,68 patients had depression,with a prevalence of 25. 8%. The two groups were not significantly different（ P 0. 05） in visuospatial,language and attention score;group A was lower（ P 0. 05） than group B in the scores of immediate memory and delayed memory and RBANS standard score. After covariance analysis,group A was lower than group B in the score of delayed memory（ F = 5. 1,P 0. 05）. The Pearson correlation analysis showed that the SDS standard score had linear negative correlation with the scores of immediate memory（ r =-0. 14,P 0. 05） and delayed memory（ r =-0. 21,P 0. 05） and RBANS standard score（ r =-0. 13,P 0. 05）. The multivariate linear regression analysis showed that SDS standard score was an influencing factor for the delayed memory for T2 DM patients（ b =-0. 22,β =-0. 21,t =-3. 00,P 0. 05）. Conclusion Depression could aggravate the cognitive injury of T2 DM patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第35期4337-4339,4343,共4页
Chinese General Practice
关键词
糖尿病
2型
认知
抑郁
Diabetes mellitus
type 2
Cognition
Depression
