摘要
目的研究多种肿瘤标记物在宫颈癌早期诊断及治疗效果判断的意义。方法检测216例宫颈癌患者治疗前后和非肿瘤患者血清CEA、CA125、CA19-9、SCC-Ag水平。结果宫颈癌患者治疗前血清CEA、CA125、CA19-9、SCC-Ag水平明显高于无肿瘤患者,比较差异有统计学意义(P<0.05);患者治疗后,血清CEA、CA125、CA19-9、SCC-Ag水平低于治疗前,比较差异有统计学意义(P<0.05);治疗前Ⅲ和Ⅳ期宫颈癌患者血清CEA、CA125、CA19-9、SCC-Ag阳性率明显高于Ⅰ、Ⅱ期的患者,其中Ⅰ期患者的CEA、CA19-9阳性率为0,差异有统计学意义(P<0.05);鳞癌患者SCC-Ag阳性率明显高于腺癌患者,差异有统计学意义(P<0.05)。结论血清CEA、CA125、CA19-9、SCC-Ag检测可协助临床宫颈癌分期诊断及其治疗效果的判定。
Objective To study the significance of various tumor markers in the early diagnosis and treatment effect judgment of cervical cancer.Methods Serum CEA,CA125,CA19-9and SCC-Ag levels were tested in 216 cases of cervical cancer and the patients with non-tumor.Results The levels of CEA,CA125,CA19-9and SCC-Ag before treatment in the patients with cervical cancer were significantly higher than those in the patients with non-tumor,the differences were statistically significant（P〈0.05）;the levels of CEA,CA125,CA19-9and SCC-Ag after treatment were significantly lower than before treatment,the differences were statistically significant（P〈0.05）;the positive rate of CEA,CA125,CA19-9and SCC-Ag before treatment in the patients with the stageⅢ and Ⅳ of cervical cancer were significantly higher than those with the stageⅠ andⅡ of cervical cancer patients,in which the positive rate of CEA and CA19-9in the stageⅠ was 0（P〈0.05）;.the positive rate of SCC-Ag in the patients with squamous cell carcinoma was significantly higher than that in the patients with adenocarcinoma,the difference was statistically significant（P〈0.05）.Conclusion The serum CEA,CA125,CA19-9and SCC-Ag level detection can assist in the staging diagnosis of clinical cervical cancer and judgment of the treatment effect of cervical cancer.
出处
《国际检验医学杂志》
CAS
2016年第1期21-23,共3页
International Journal of Laboratory Medicine
关键词
宫颈癌
肿瘤标记物
早期诊断
疗效判定
cervical carcinoma
tumor marker
early diagnosis
judgment of treatment effect
