摘要
目的:观察临床治疗获益的晚期非小细胞肺癌患者进行自体DC-CIK维持治疗前后生活质量的变化情况。方法:选择规范综合治疗后获益的Ⅲb期或Ⅳ期非小细胞肺癌患者,分为A、B两组,每组25例。A组给予自体DC-CIK维持治疗1个疗程,B组予中成免疫药物(康艾注射液)治疗10天。采用QLICP-LU量表测定患者在入组时、入组后2月的生活质量。统计治疗前后患者的生活质量评分,并分析影响自体DC-CIK治疗效果的因素,观察治疗的安全性。结果:自体DC-CIK维持治疗后患者的生活质量在躯体功能、癌症共性症状和副作用以及肺癌特异性症状等方面较康艾针治疗后的患者有所改善(P<0.05);通过亚组分析得出,自体DC-CIK维持治疗对鳞癌、IV期、年龄大于60岁的男性肺癌患者的生活质量改善较为明显。维持治疗期间未出现严重的骨髓抑制、肝肾毒性及消化道反应,总不良反应发生率4%。结论:自体DC-CIK作为60岁以上临床治疗获益的IV期肺鳞癌男性患者的维持治疗手段,能通过对躯体功能、癌症共性症状和副作用以及肺癌特异性症状等方面的改善,提高患者生活质量,且毒副反应能耐受。
Objective： To determine the effect of DC-CIK maintenance therapy on the quality of life in advanced non-small cell lung cancer（ NSCLC） patients. Methods： Fifty patients with stage Ⅲb or IV NSCLC who achieved complete remission,partial remission or stable disease after standard treatment were divided into two groups equally and randomly. Group A was treated with a course of autologous DC-CIK maintenance treatment,and group B was treated with immunosuppressive drugs（ Kang Aizhen） for 10 days. The quality of life of patient was measured by QLICP-LU scale at the time of hospitalized and two months after treatment. Scores of quality of life pre- and post-treatment and factors related to therapeutic effect were analyzed,furthmore,the safety of treatment was also evaluated. Results： The qualities of life in NSCLC patients were improved after DC-CIK maintence therapy（ P〈0. 05）. The qualities of life were improved significantly in squamous cell cancer,stage IV,aged over 60 years male patients after DC-CIK maintenance treatment. Total incidence of adverse reaction was 4% and no severe bone marrow suppression,liver and kidney toxicity and gastrointestinal tract reaction were observed during treatment period. Conclusion： Autologous DC-CIK treatment has potential benefit for the qualities of life of male patients who age over 60 years and with stage IV squamous cell lung cancer with acceptable side effects. It is a safe and effective method for maintenance therapy.
出处
《肿瘤预防与治疗》
2015年第6期322-329,共8页
Journal of Cancer Control And Treatment
基金
贵州省优秀科技教育人才省长专项资金项目(黔省专合字:2009-46号)
