严重多发伤患者外周血中性粒细胞中核因子κB与炎症介质的变化被引量：1

Change of peripheral blood neutrophil nuclear factor κB and inflammation mediators of patients with severe multiple injuries

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摘要目的探讨及观察严重多发伤患者外周血中性粒细胞中核因子κB与炎症介质的变化。方法选择2013年3月-2015年4月于四川省人民医院进行治疗的65例严重多发伤患者为观察组,选取同期进行体检健康者65名为对照组,然后将观察组伤后24、48 h及72 h时的外周血中性粒细胞中核因子κB与抗炎介质、促炎介质水平与对照组分别进行比较,并将观察组中非多器官功能障碍综合征（MODS）与MODS者、存活与死亡者的上述检测指标水平分别进行比较。结果观察组伤后24、48 h及72 h时的外周血中性粒细胞中核因子κB与抗炎介质、促炎介质水平均明显高于对照组,且伤后48、72 h的外周血中性粒细胞中核因子κB高于伤后24 h,伤后72 h的抗炎介质、促炎介质水平高于伤后24 h,且观察组中MODS及死亡者的检测水平均高于非MODS及存活者,差异均有统计学意义（均P〈0.05）。结论外周血中性粒细胞中核因子κB与炎症介质在严重多发伤患者中的检测价值较高,对患者的预后有一定的预测价值。 Objective To investigate and observe the change of peripheral blood neutrophil nuclear factor kB and inflammation mediators of patients with severe multiple injuries.Methods 65 patients with severe multiple injuries from March 2013 to April 2015 in Sichuan Provincial People＇s Hospital were selected as observation group,65 healthy persons with health examination at the same time were selected as control group,then the peripheral blood neutrophil nuclear factor kB,anti-inflammatory mediators and pro-inflammatory mediators of observation group at 24,48 h and 72 h after injury and control group were respectively compared,and those detection indexes of observation group with nonMODS and MODS,survival and death were respectively compared too.Results The peripheral blood neutrophil nuclear factor kB,anti-inflammatory mediators and pro-inflammatory mediators of observation group at 24,48 h and 72 h after injury were all obviously higher than those of control group,and the peripheral blood neutrophil nuclear factor kB of the observation group at 48 h and 72 h after injury were higher than 24 h after injury,and the anti-inflammatory mediators and pro-inflammatory mediators at 72 h after injury were higher than 24 h after injury,the detection levels of observation group with MODS and death were higher than those of non-MODS and survival,the differences were statistically significant（all P〈0.05）.Conclusion The detection value of peripheral blood neutrophil nuclear factor kB and inflammation mediators of patients with severe multiple injuries is high,and it has certain value for prediction of patients＇ prognosis.

作者李伟曾杰

机构地区四川省人民医院急诊外科

出处《中国医药导报》 CAS 2016年第1期62-65,70,共5页 China Medical Herald

基金四川省卫生计生委科研项目(140088)

关键词外周血中性粒细胞核因子ΚB 炎症介质严重多发伤 Peripheral blood neutrophil Nuclear factor κB Inflammation mediators Severe multiple injuries

分类号 R651.15 [医药卫生—外科学]