摘要
目的:观察针灸序贯疗法对卵巢储备功能下降(DOR)患者卵巢功能及体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法:将63例采用体外受精(IVF)/卵细胞浆内单精子注射(ICSI)的DOR患者随机分为观察组(30例)、对照组(33例)。观察组采用针灸序贯治疗,在月经周期不同阶段依次采取辨证治疗,即月经期穴取十七椎、命门;经后期穴取肾俞、膈俞、三阴交、太溪;排卵期穴取气海、关元、子宫、足三里;经前期穴取气海、关元、阳陵泉、太冲,每周2次,针灸至第2个月经周期取卵前,总疗次为(15±2)次,针灸结束后接受IVF-ET周期治疗。对照组不予针灸疗法直接进入IVF-ET周期治疗。分析比较观察组治疗前后卵巢储备功能指标[基础卵泡刺激素(FSH)、雌二醇(E_2)、窦卵泡数(AFC)、获卵数、受精数、优质胚胎数);同时比较两组患者IVF-ET周期治疗结局(周期取消率、胚胎种植率、临床妊娠)的差异。结果:观察组序贯针灸治疗后,人绒毛膜促性腺激素(HCG)日E_2值、窦卵泡数、获卵数、受精数、优质胚胎数均较针灸治疗前增加(均P<0.05);HCG日E_2值、获卵数、受精数、优质胚胎数较对照组均显著增加(均P<0.05),胚胎种植率、临床妊娠率明显提高(均P<0.01),周期取消率低于对照组(P<0.01)。结论:针灸序贯疗法能有效改善DOR患者的卵巢储备功能,进而提高体外受精-胚胎移植的临床妊娠率。
Objective To observe the effects of ＂menstrual cycle-based acupuncture therapy＂on ovarian function and pregnancy results of in vitro fertilization-embryo transfer（IVF-ET）in patients with decline in ovarian reserve（DOR）.Methods A total of 63 patients of DOR who received treatment of IVF/intracytoplasmic sperm injection（ICSI）were randomly divided into an observation group（30 cases）and a control group（33 cases）.The patients in the observation group were treated with ＂menstrual cycle-based acupuncture therapy＂.The syndrome differentiation and treatment were given based on different phases of menstruation.Shiqizhui（EX-B 8）and Mingmen（GV 4）were selected during menstrual phase,Shenshu（BL 23）,Geshu（BL 17）,Sanyinjiao（SP 6）and Taixi（KI 3）were selected after menstruation,Qihai（CV 6）,Guanyuan（CV 4）,Zigong（EX-CA 1）,Zusanli（ST 36）were selected during ovulatory period,Qihai（CV 6）,Guanyuan（CV 4）,Yanglingquan（GB 34）,Taichong（LR 3）were selected before menstruation.The acupuncture was given twice a week until second menstrual cycle of oocyte retrieval.The total times of acupuncture was（15±2）.After acupuncture,patients were treated with IVF-ET.The patients in the control group were treated with IVF-ET but no acupuncture.The indices of ovarian reserve function,including basic follicle-stimulating hormone（FSH）,estradiol（E2）,antral follicle count（AFC）,number of retrieved oocytes,number of fertilization and number of high quality embryo,were compared and analyzed before and after acupuncture in the observation group.The differences of outcomes of IVF-ET,including the cycle cancellation rate,implantation rate,the clinical pregnancy rate,were compared between the two groups.Results Compared before acupuncture,the E2,AFC,number of retrieved oocytes,number of high quality embrgo and number of fertilization were all increased after acupuncture in the observation group（all P〈0.05）.Compared with the control group,levels of the E2,the numb
出处
《中国针灸》
CAS
CSCD
北大核心
2016年第1期25-28,共4页
Chinese Acupuncture & Moxibustion
基金
国家自然科学基金资助项目:81473767
关键词
卵巢储备功能降低(DOR)
针灸序贯疗法
体外受精-胚胎移植
随机对照试验
decline in ovarian reserve（DOR）
menstrual cycle-based acupuncture therapy
in vitro fertilization-embryo transfer（IVF-ET）
randomized controlled trial（RCT）
