摘要
目的观察较低剂量氟哌噻吨美利曲辛联合雷贝拉唑和莫沙必利对非糜烂性胃食管反流病伴述情障碍患者的临床疗效。方法选择2014年1月至2015年1月解放军第一〇〇医院消化科门诊收治的非糜烂性胃食管反流病伴述情障碍患者60例，按照随机数字表法分为观察组和对照组，各30例。对照组给予雷贝拉唑肠溶片20 mg口服，1次/d，枸缘酸莫沙必利分散片5 mg，口服，3次/d；观察组在对照组的基础上加用氟哌噻吨美利曲辛片10.5 mg，1次/d，早餐前口服。2组疗程均为8周。比较2组患者治疗第1天及治疗8周后反流性疾病诊断问卷（RDQ量表）评分、Zung焦虑自评量表（SAS）评分和Zung抑郁自评量表（SDS）评分，并比较2组患者临床有效率和不良反应发生情况。结果治疗8周后，2组患者RDQ量表评分、SAS评分、SDS评分均明显低于治疗第1天［观察组：（6.1±1.5）分比（12.2±1.7）分、（36±10）分比（54±11）分、（36±10）分比（50±12）分，对照组：（9.1±1.6）分比（11.3±1.5）分、（53±11）分比（55±11）分、（46±11）分比（48±12）分］，且观察组均明显低于对照组，差异均有统计学意义（均P＜0.05）。观察组治疗总有效率明显高于对照组［93.3%（28/30）比60.0%（18/30）］，差异有统计学意义（P＜0.05）。观察组有4例出现口干、口苦，对照组6例出现嗜睡，经休息后很快缓解，不影响继续治疗。结论较低剂量氟哌噻吨美利曲辛联合应用雷贝拉唑和莫沙必利能够提高非糜烂性胃食管反流病伴述情障碍患者的疗效。
ObjectiveTo observe the effect of low dose flupentixol and melitracen tablets combined with rabeprazole, mosapride in treating non-erosive gastroesophageal reflux disease complicated with alexithymia. MethodsTotally 60 patients with non-erosive gastroesophageal reflux disease complicated with alexithymia from January 2014 to January 2015 were randomly divided into observation group and control group （30 cases in each groups）. Control group was given oral administration of rabeprazole （20 mg/time, once daily） and mosapride （5 mg/time, 3 times/d）; observation group was additionally given oral administration of flupentixol and melitracen tablets （1 tablet, once daily before breakfast）. The treatment was lasted for 8 weeks. The reflux disease diagnostic questionnaire （RDQ scale） score, Zung self rating anxiety scale （SAS） score and Zung depression self rating scale （SDS） score on the 1st day and 8 weeks after treatment were assessed; the effective rate and incidence of adverse reaction were compared between groups. ResultsThe RDQ scale score, SAS scores and SDS score after 8 weeks of treatment were significantly lower than those on the first day after treatment in observation group [（6.1±1.5） scores vs （12.2±1.7） scores, （36±10） scores vs （54±11） scores, （36±10） scores vs （50±12） scores] and control group [（9.1±1.6） scores vs （11.3±1.5） scores, （53±11） scores vs （55±11） scores, （46±11） scores vs （48±12） scores], all the scores were significantly lower in observation group than those in control group 8 weeks after treatment （P〈0.05）. The effective rate in observation group was significantly higher than that in control group [93.3%（28/30） vs 60.0%（18/30）] （P〈0.05）. Four cases in observation group had dry mouth and bitter mouth, 6 cases in control group had with drowsiness. ConclusionLow dose flupentixol and melitracen tablets combined with rabeprazole, mosapride can enhance the effect in treating ulceratie gastro
出处
《中国医药》
2016年第1期62-66,共5页
China Medicine
关键词
非糜烂性胃食管反流病
氟哌噻吨美利曲辛
雷贝拉唑
莫沙必利
述情障碍
Non-erosive gastroesophageal reflux disease；Flupentixol and melitracen tablets；Rabeprazole；Mosapride；Alexithymia
