摘要
目的 研究长期口服肠溶阿司匹林对中老年脑出血及颅脑损伤手术的影响。方法 回顾性分析2013年6月-2015年6月在我院神经外科接受手术治疗的脑出血和颅脑损伤患者132例,按照患者术前是否长期服用肠溶阿司匹林情况分为：A组长期规律服用38例,B组长期间断服用45例,C组未服用49例,并对各组病例术前凝血功能、术中出血量、术后72 h内再出血情况进行比较。结果 A、B、C三组凝血酶原时间分别为（13.59±0.24）s、（13.36±0.19）s、（13.12±0.12）s;术中出血量分别为（707.89±38.02）mL、（711.11±33.93）mL、（523.47±26.77）mL;术后再出血患者分别为8例（21.05%）、9例（20.00%）、2例（4.08%）。术后1个月随访,A组死亡4例,B组死亡5例,C组死亡1例。A组与C组、B组与C组之间术中出血量差异有统计学意义（P〈0.05）;A组与C组、B组与C组之间术后再出血发生率差异有统计学意义（P〈0.05）;A组与B组之间术中出血量和术后再出血发生率比较,差异无统计学意义（P〉0.05）。A、B、C三组凝血酶原时间比较差异无统计学意义（P〉0.05）。结论 长期服用肠溶阿司匹林能增加脑出血及颅脑损伤术中的出血量,增大术后再出血率。
Objective To explore the effects of long-term orally-administrative enteric coated aspirin in surgeries on middle-aged and old patients with cerebral hemorrhage and craniocerebral injury.Methods A total of 132 patients with cerebral hemorrhage and craniocerebral injury receiving surgery in our hospital of Neurosurgery Department from June2013 to June 2015 were.reviewed and analyzed.The patients were divided into three groups according to whether had lpng-termly taken enteric coated aspirin before operation：the long-term and regular group（group A,n=38）,the longterm and discontinuous group（group B,n=45）,and the not-taking group（group C,n=49）.The preoperative coagulation function,intraoperative blood loss,72 h postoperative rehaemorrhagia of each group were compared and analyzed.Results The prothrombin time of patients in group A,B,and C were（13.59±0.24）s,（13.36±0.19）s,and（13.12±0.12）s,respectively.The intraoperative blood losses were（707.89±38.02）mL,（711.11±33.93）mL,and（523.47±26.77）mL,respectively.And the cases of patients experiencing postoperative rehaemorrhagia were 8 cases（21.05%）,9 cases（20.00%）,and2 cases（4.08%）.According to the follow up visit 1 month after operation,4 patients died in group A,5 cases and 1 case died in group B and C,respectively.The differences of intraoperative blood losses between group A and group C,and between group B and group C were statistically significant（P〈0.05）.The differences of incidences of postoperative rehaemorrhagia between group A and group C,and between group B and group C were statistically significant（P〈0.05）.There was no significant difference in intraoperative blood loss and postoperative rehaemorrhagia between group A and group B（P〉0.05）.The prothrombin time of three groups had no significant difference（P〉0.05）.Conclusion Longterm oral administration of enteric coated aspirin can increase the blood loss during cerebral hemorrhage and craniocerebral injury surgeries and enhance the incide
出处
《中国现代医生》
2015年第36期100-102,共3页
China Modern Doctor
关键词
肠溶阿司匹林
脑出血
颅脑损伤
术后再出血
Enteric coated aspirin
Cerebral hemorrhage
Craniocerebral injury
Postoperative rehaemorrhagia
