摘要
泊沙康唑为新一代三唑类广谱抗真菌药,临床主要用于侵袭性曲霉菌病、念珠菌病的预防和难治性口咽念珠菌病的治疗,具有抗菌活性高、耐受性好、不良反应少等特点,但其口服后生物利用度具有较大的个体差异。综述泊沙康唑混悬液的药动学影响因素、不同患者人群的药动学特征以及群体药动学特征、药动学/药效学特性、治疗药物监测对临床疗效和不良反应的重要影响,以指导临床个体化用药,提高用药的有效性和安全性。
Posaconazole is a new-generation azole antifungal agent which is used for prophylaxis of invasive Aspergillus and Candida infections and treatment of refractory oropharyngeal candidiasis. Despite its high antimicrobial activity, good tolerability and less adverse reactions, considerable individual variations in pharmacokinetics have been observed. In this article, pharmacokinetics affecting factors, pharmacokinetic characteristics in different patient populations, population pharmacokinetics, pharmacokinetics/pharmacodynamics and the infl uence of therapeutic drug monitoring on clinical efficacy and adverse reactions were reviewed for posaconazole, so as to provide guidance for individualized therapy and to improve drug efficacy and safety.
出处
《药学进展》
CAS
2015年第11期810-816,共7页
Progress in Pharmaceutical Sciences
关键词
泊沙康唑
药动学
药效学
群体药动学
治疗药物监测
posaconazole
pharmacokinetics
pharmacodynamics
population pharmacokinetics
therapeutic drug monitoring
