摘要
目的:探讨玫瑰花总黄酮对脂多糖(LPS)诱导的大鼠乳腺炎的影响。方法:脂多糖注射诱导大鼠乳腺炎,观察玫瑰花总黄酮(200,100 mg·kg^(-1)·d^(-1))给药干预对乳腺组织切片形态学变化、乳腺氧化应激和炎症应激水平的影响。结果:与对照组相比,LPS注射导致大鼠乳腺组织大量炎性细胞浸润,SOD和GPx的活力显著下降,同时MDA水平大幅上升,组织IL^(-1)β、IL-6和TNF-α的水平均显著升高。与模型组比较,低剂量组和高剂量组均能显著改善模型动物乳腺的病理变化,恢复乳腺组织抗氧酶SOD和GPx的活力(P<0.05或P<0.01),降低了MDA的水平(P<0.01),并抑制促炎细胞因子IL^(-1)β、IL-6和TNF-α水平的上升(P<0.05或P<0.01)。结论:玫瑰花总黄酮有潜在的抗乳腺炎活性。
Objective： To assess the effect of total flavonoids from Rosa rugosa （FRR） on mastitis induced by lipopolysaccharide （LPS） in rats. Methods： The experimental rat model was induced by injection of LPS. The rats were treated with FRR （200 or 100 mg· kg-1· d- 1 ）, and then the morphology changes, oxidative stress and inflammatory stress in mammary tissue were observed. Results： The rat mammary injected with LPS was infiltrated by a large number of inflammatory eells, the activity of SOD and GPx was decreased significantly, and the level of MDA, IL-1β, IL-6 and TNF-α in the tissue was increased notably when compared with there in the control group. Compared with the model group, both low-dose group and high-dose group could significantly improve the pathological changes, as well as restore the levels of antioxidant enzyme SOD and GPx （P 〈0.05 or P 〈0.01 ） ,and decrease the level of MDA （ P 〈 0.01 ） and the level of inflammatory cytokines IL-1β, IL-6 and TNF-α （ P 〈 0.05 or P 〈 0.01 ）. Conclusion： FRR shows potential anti-mastitis activity in rats.
出处
《中国药师》
CAS
2016年第1期33-35,共3页
China Pharmacist
基金
湖北省自然科学基金项目(编号:2013CFB361)
关键词
玫瑰花
乳腺炎
氧化应激
炎症应激
Rosa rugosa
Total flavonoids
Oxidative stress
Inflammatory stress
