摘要
目的研究伴中央颞区棘波的儿童良性癫痫(BECT)患儿经奥卡西平单药治疗6个月后其注意网络的变化。方法运用注意网络测试工具(ANT)对服用奥卡西平治疗6个月前后的BECT患儿进行注意网络测试。结果在奥卡西平治疗6个月过程中,76.1%的BECT患儿未有发作,13.0%的患儿发作次数较用药前减少≥50%。71.8%的患儿在奥卡西平治疗6个月后脑电图异常放电得到缓解。BECT患儿经奥卡西平治疗6个月后(T1阶段)注意网络总反应时(876.00±186.68)ms低于治疗前基线水平(T0阶段)(956.76±190.38)ms,差异有显著统计学意义(t=4.111,P=0.000)。T1阶段注意网络检查正确率(97.46±3.20)ms高于T0阶段(95.76±5.38)ms,差异有显著统计学意义(t=-2.578,P=0.013)。警觉网络功能效率比较,T1阶段73(40,99)ms高于T0阶段45(17,84)ms,差异有统计学意义(z=-2.125,P=0.034);定向网络效率T1阶段32(-6,71)ms高于T0阶段3(-27,57)ms,差异有统计学意义(z=-2.213,P=0.027)。治疗前后执行网络功能效率差异无明显统计学意义(P>0.05)。结论奥卡西平可改善BECT患儿的临床发作及脑电图异常放电并可改善患儿注意网络功能,特别是警觉网络功能。
Objective： To investigate the attention networks evaluation in children with benign epilepsy with centrotemporal spikes （BECT） treated by oxcarbazepine （OXC） therapy. Methods： Attention networks assessment was performed at baseline and after 6 months treatment with the efficiency of three anatomicaly defined attention networksalerting, orienting, and executive control. Results： 46 children were completed the research, During the follow-up, sustained cessation of seizures under medication was observed in 76.1% of patients; 13.0% experienced 〉/50% improvement, and 10.9% showed no improvement. Meanwhile, 71.8% showed an improvement in the grade of electroencephalographic pathology, and 24% manifested no change at all. There was no normalization of interictal epileptiform activity was observed. The Grand mean effect of attention network test was significantly lower （P 〈 0.05） in T1 （after 6 months of OXC therapy） （876.00＋186.68） ms than that in T0 （baseline） （953.93±177.05） ms. The correct rate of attention network test was significantly higher （P 〈 0.055 in T1 （97.46＋3.20） ms than that in TO （95.76＋_5.38） ms. The alerting networks effects （73 （40, 99） ms） was higher in T1 than in TO （45 （17, 84） ms） with significant difference, The orienting networks effects （32 （-6, 71） ms） was higher in Tt than in TO （18 （-22, 56） ms） with significant difference, however, we found no significant difference in the executive control networks effects. Conclusion： The current study suggested that OXC may effective in preventing seizures and normalizing electroencephalograms and seems to preserve attention network functions as short-term monotherapy in children with typical BECTS.
出处
《中国优生与遗传杂志》
2016年第1期121-124,共4页
Chinese Journal of Birth Health & Heredity
关键词
伴中央颞区棘波的儿童良性癫痫
注意网络
奥卡西平
Benign epilepsy children with centrotemporal spikes
Attention Networks
Oxcarbazepine
