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糖化血红蛋白水平与2型糖尿病合并心力衰竭患者心功能的相关性研究 被引量:7

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摘要 目的探讨糖化血红蛋白(HbA1C)与2型糖尿病合并慢性心力衰竭患者心功能的关系。方法将126例2型糖尿病合并慢性心力衰竭患者按照入院时HbA1C的控制水平将分为4组:Ⅰ组HbAlC〈7.0%、Ⅱ组7.0%~8%、Ⅲ组8.1%~9.0%、Ⅳ组为〉9.0%。测定所有患者入院时N末端B型钠尿肽原(NT-proBNP),记录入院时的心脏超声指标。同时将所有患者NT-proBNP水平按照中位数分为两组:A组(〈2225.1 pg/ml)B组(≥2225.1 pg/ml),比较各组相关指标的差异。结果 4组糖尿病病程、空腹血糖(FPG)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)及NT-proBNP差异均有统计学意义(均P〈0.05);A组患者的HbA1C低于B组,入院时血糖控制情况(HbAlC水平分级)亦优于B组(均P〈0.05);HbA1C水平与NT-proBNP呈正相关而与LVEF呈负相关(P〈0.05);HbA1C水平是影响NT-proBNP水平的独立危险因素。结论 HbA1C水平控制情况与2型糖尿病合并慢性心力衰竭患者心功能密切相关,临床应积极控制HbA1C水平进而提高心衰患者血糖达标率,对延缓心功能恶化,提高患者预后有重要意义。
作者 徐莉娜
出处 《现代实用医学》 2015年第12期1630-1632,共3页 Modern Practical Medicine
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参考文献12

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