摘要
目的探讨胃癌腹水应用顺铂、5-氟尿嘧啶(5-FU)序贯腔内给药治疗,同时联合内生场热疗的疗效。方法选取2009-2012年吉林省肿瘤医院腹部肿瘤外二科收治的胃癌性腹水患者76例,按不同治疗方法分为治疗组(39例)和对照组(37)例。治疗组:腹腔内化疗,每周1次,联合局部内生场热疗,每周2次;连续治疗2周后休息1周。对照组:单纯腹腔内化疗,每周1次。观察两组患者的疗效和不良反应。结果治疗组患者有效率为89.74%,而对照组为67.57%,两组间比较差异有统计学意义(P<0.05)。两组患者治疗后不良反应主要表现为恶心、食欲下降、乏力,偶见低热、腹痛和一过性白细胞下降,且均在可控范围内。结论腹腔内化疗联合内生场热疗能有效地控制胃癌性腹水,不良反应较轻。
Objective To explore the efficacy of cisplatin and 5-fluorouracil（5-FU）sequential administration of the treatment cham- ber, while the joint effect of hyperthermia within the field of health, for the treatment of malignant ascites suffered from gastric canc- er. Methods Totally 76 patients received from 2009 to 2012 in our department were analyzed in this study. In the treatment group （39 cases） , 1 time per week intraperitoneal chemotherapy combined with local was performed ,2 times a week;continuous treatment for 2 weeks after 1 week rest. While, in the control group （37 cases）, simple intraperitoneal chemotherapy was performed, once a week. The efficacy and adverse reactions were observed in all cases of the two groups. Results The effective rate was 89.74% in the treatment group,while that was 67.57% in the control group, and there was statistical difference between the 2 groups（ P 〈 0.05 ）. Side effects were mainly nausea,loss of appetite, fatigue, occasional fever, abdominal pain and transient leukopenia. Conclu- sion Intraperitoneal chemotherapy combined with hyperthermia within the field of health can effectively control the field of hyper- thermia cancer ascites,reducing adverse reactions. Thermo-chemotherapy can improve local and systemic cellular immune function and may inhibit tumor angiogenesis effect.
出处
《临床军医杂志》
CAS
2015年第7期729-732,共4页
Clinical Journal of Medical Officers
关键词
胃癌性腹水
顺铂
5-氟尿嘧啶
内生场热疗
Malignant ascites
Cisplatin
5-fiuorouracil
Endogenous field hyperthermia
