摘要
中药有效成分组是指中药复方中所含有的所有与该复方临床应用目的密切相关的药理活性成分,是中药复方系统中起核心作用的一个子系统。其基本性质保持了中药复方多成分和具有系统整体性的特点,又有化学成分明确的特征。然而因中药的复杂性,目前对其研究成功的案例仍然较少。通过对近年来有效成分组优秀研究案例进行分析总结,归纳了"基于化学成分中药药性辨析的拆方-组方研究""基于色谱指纹图谱敲入敲出思想的有效成分组筛选"和"基于中药血清药物化学的有效成分组筛选"3种有效成分组的构建策略,以及对中药有效成分组的"多成分组合""化学成分明确"和"系统整体性"3个方面性质的表征方法,为今后的中药有效成分组研究提供思路。
Effective compounds group of Chinese materia medica（CMM） is a pharmacological active compounds group containing all components that are closely related to their clinical application. It plays a core role in CMM formula. We think it maintains not only the characteristics of the whole system and the system integrity of CMM formula, but also their chemical compositions are clear. However, due to the complexity of CMM, the successful research cases are very few. In this paper, we summarized several outstanding research cases of effective compounds group in recent years and there are three strategies, including ＂research on decomposed-combined recipes of CMM based on assessment of chemical components in CMM way＂, ＂screening the effective components group based on knock-in and knock-out from chromatographic fingerprint＂, and ＂screening the effective components group based on serum pharmacochemistry＂. We also summarized the ways to illustrate properties of effective compounds group, such as combination of multiple component, clear chemical composition, and system integrity. This paper provided ideas for the future research of effective components of CMM.
出处
《中草药》
CAS
CSCD
北大核心
2015年第22期3289-3296,共8页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81403191
81460631)
云南省科学研究基金资助项目(2013Y324)
昆明理工大学药物代谢平台建设项目(14078184)
关键词
中药有效成分组
研究方法
拆方-组方研究
敲入敲出筛选
血清药物化学
effective compounds group
research methods
decomposed-combined recipes
knock-in and knock-out screening
serum pharmacochemistry
