摘要
目的探讨血清γ谷氨酰胺转肽酶(γ-GT)对食管鳞癌患者预后的预测价值。方法回顾性分析83例食管鳞癌患者的临床病理资料,按γ-GT表达高低分为高危组和低危组,采用Kaplan-Meier法及Cox回归分析明确γ-GT与预后的关系。结果高危组和低危组患者的1年生存率分别为75.6%和90.2%,2年生存率分别为56.7%和80.3%,3年生存率分别为43.1%和68.8%,两组患者的远期生存情况差异有统计学意义(P=0.015)。Cox风险比例回归分析显示,年龄≥60岁(P=0.032)、肿瘤分期晚(Ⅲ期,P=0.045)、术后无治疗(P=0.017)和治疗前血清γ-GT水平≥22.5 U/L(P=0.022)均为预后不良的影响因素。结论治疗前血清γ-GT水平或可用于预测食管鳞癌患者的预后。
Objective To explore the prognostic value of serum γ-GT in patients with esophageal squamous cell cancer. Method The clinical data of 83 cases of esophageal squamous cell cancer were retrospectively analyzed, and all patients were grouped as high-risk or low-risk by the expression level of serum γ-GT. The Kaplan-Meier method and Cox regression model were used to investigate the association between serum γ-GT and prognosis. Result The 1-year, 2-year, and 3-year survival rates in high- vs low-risk group were 75.6% vs 90.2%, 56.7% vs 80.3%, and 43.1% vs 68.8%, respectively, and there was significant differences in regards of long-term survival of the two groups （P=0.015）. In the Cox proportional hazards regression model, the age （P=0.032）, advanced stages （P=0.045）, discon-tinued treatment after operation （P=0.017） and a pre-operative level of γ-GT ≥ 22.5 U/L （P=0.022） were all signifi-cantly associated with poor prognosis. Conclusion The pre-operative level of serum γ-GT may be used to predict the prognosis of patients with esophageal squamous cell cancer.
出处
《癌症进展》
2015年第6期642-645,共4页
Oncology Progress
