摘要
目的探讨老年慢性充血性心衰（CHF）患者甲状腺激素水平变化及其临床意义。方法采用化学发光法测定100例心功能Ⅱ~Ⅳ级患者（心衰组）和44例心功能正常患者（对照组）血清甲状腺素水平,包括总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）、促甲状腺素（TSH）,同时进行比较分析。随后将心衰组进行常规抗心衰治疗1个月后再次复查甲状腺激素水平,观察治疗前后各指标变化。结果与对照组比较,心衰组TT3水平明显降低（P〈0.01）,且随心功能程度加重,降低越明显,在心功能IV时还伴有TT4下降（P〈0.01）,而TSH各组间与对照组比较无明显变化（P〉0.05）。心衰组经抗心衰治疗后TT3水平有所恢复,差异有统计学意义（P〈0.05）。结论动态监测心衰患者TT3水平变化可作为评价心衰严重程度、治疗效果及预后的一项指标。
Objective To investigate the changes of thyroid hormone in elderly patients with chronic congestive heart failure （CHF）. Methods The levels of（TT3） ,（TT4） and Thyrotropin（TSH） from 100 CHF patients of class Ⅱ-Ⅳ（heart failure group） and 44 normal subjects （ control group） were determined by chemiluminescent immunoassay, and the difference was compared between these two groups. Then heart failure group were treated for one month and the thyroid hormone were compared before and after treatment. Results Compared with the control group, the content of TT3 in patients of heart failure group after treatment were significantly lower than that before treatment（ P 〈 0.01 ） , with poorer heart failure ,lower level of T33. At the same time, the level of TT4 in the CHF patients （ NYHA Ⅳ ） dropped （ P 〈 0.01 ）. While, there was no difference between these two groups （ P 〉 0. 05 ）. The level of TT3 of patients in heart failure group had been restored after anti-heart failure threatment, and there were significant differences （ P 〈 0.05 ）. Conclusion The level of TT3 may be used as an index of severity,therapeutic effect and prognosis of heart failure in CHF patients.
出处
《临床军医杂志》
CAS
2015年第8期778-780,共3页
Clinical Journal of Medical Officers
