摘要
目的探讨幼年类风湿关节炎患者（JRA）血清中类风湿因子（RF）、抗角蛋白抗体（AKA）、抗核周因子（APF）与抗环瓜氨酸多肽（CCP）抗体的相关性。方法收集2012年1月-2013年1月儿童风湿病科门诊及住院确诊的幼年类风湿关节炎（JRA）确诊患者100例，其中男性62例，女性38例，幼年其它风湿病患者69例，健康对照儿童50例血清标本，检测其血清中抗CCP抗体及RF，AKA和APF四种指标，分析抗CCP抗体与RF，AKA和APF的相关性及各项指标联合检测的敏感度和特异度。结果100例JRA组中抗CCP抗体，RF，AKA和APF阳性率分别为48％，25％，28％和34％；69例幼年其它风湿病患者组中阳性率分别为2．89％，4．35％，1．45%和1．45％，50例健康对照组各指标均为阴性。抗CCP抗体在JRA组阳性率与幼年其它风湿病组及健康对照组比较差异有统计学意义（χ^2=22．1，43．7，P〈0．001）。在JRA组中，抗CCP抗体，RF，AKA和APF的敏感度分别为48％，25％，28％和34％，特异度分别为98．3％，97．5％，98．8％和98．8％，抗CCP抗体测定对JRA有较高的敏感度和很好的特异度，敏感度与RF，AKA和APF比较差异均有统计学意义（χ^2=46．1，38．2，31．7，P〈0．01），特异度差异无统计学意义（P〉0．05），抗CCP抗体与RF，AKA和APF这三种指标的重叠阳性率分别为21％，24％和31％，结果相符率分别为69％，72％和80％。经Kendalls Taub相关性检验分析，结果显示抗CCP抗体与RF，AKA和APF的相关系数分别为r=0．387，0．451和0．401；均P〈0．01，抗CCP抗体与RF，AKA和APF之间均存在相关性。结论抗CCP抗体对JRA有较高的敏感度和很好的特异度，抗CCP抗体与RF，AKA和APF之间存在相关性，抗CCP抗体在RF，AKA和APF均为阴性的JRA中意义重大。各项指标若能联合检测，则可较大提高JRA患者的早期诊断率，可以弥补单项检测造成的误诊或漏
Objective To discuss the correlation of rheumatoid factors （RF）, anti-keratin antibody （AKA）, anti perinuclear factors （APF） ,anti cyclic citrullinated peptide （CCP） antibody in the serum of juvenile rheumatoid arthritis （JRA） patients. Methods Tested anti-CCP antibody,RF, AKA,and APF in the serum of 100 J RA patients,69 other juvenile rheumatoid pa tients and 50 healthy control children,compared the correlation of anti-CCP antibody and RF, AKA and APF,as well as the sensitivity and specificity of joint detection of other indexes. Results In 100 JRA patients,the positive rate of anti CCP anti body,RF,AKA and APF was 48%,25%,28% and 34% respectively. In 69 other juvenile rheumatoid patients,the positive rate of anti-CCP antibody, RF, AKA and APF was 2.89%, 4.35%, 1.45% and 1.45% respectively. In 50 healthy control children, all indexes were positive. The comparative difference of positive rate of anti-CCP antibody in J RA group,other j u venile rheumatoid patients group, and healthy control group had great statistical significance （χ^2 = 22.1,43.7, P〈0. 001）. In JRA group, the sensitivity of anti-CCP antibody, RF, AKA and APF were separately 48%,25%,28% and 34%, and the specificity were separately 98.3%, 97.5%, 98.8% and 98.8%. The detection of anti-CCP antibody had high sensitivity and good specificity on JRA. Compared with RF, AKA and APF, the sensitivity of anti-CCP antibody had significant difference （χ^2 =46.1,38.2 and 31.7,all P〈0.01） ,the difference on specificity had no statistical significance （P〉0.05）. The overlap ping positive rate of anti-CCP antibody and RF, AKA and APF, were separately 21%, 24% and 31%, and corresponding rate of the results were separately 69%, 72% and 80%. According to the correlation test in Kendall＇s Tau-b method, the correla tion coefficient of anti-CCP antibody and RF, AKA and APF were separately （ r= 0. 387,0. 451,0. 401; all P〈0.01 ）, and there was correlation between anti-CCP antibody and RF,AKA and APF. Conclusion Anti-CCP anti
出处
《现代检验医学杂志》
CAS
2015年第6期136-139,共4页
Journal of Modern Laboratory Medicine
基金
西安市卫计委,项目编号：J2011013,抗CCP抗体在幼年类风湿关节炎中的诊断价值分析.
关键词
幼年类风湿关节炎
抗环瓜氨酸多肽抗体
类风湿因子
抗角蛋白抗体
抗核周因子
juvenile rheumatoid arthritis
anti-cyelic citrultinated peptide antibody
rheumatoid factors
anti-keratin antibody
anti-perinuclear factor
