摘要
目的探讨心理干预对结直肠癌根治术后化学疗法(化疗)患者免疫功能及心理状态的影响。方法选择2008年8月-2013年8月收治的64例结直肠癌根治术后化疗患者,随机分为对照组和干预组,两组均接受常规化疗和护理,干预组在常规护理基础上再进行心理干预。在治疗开始及8周后以焦虑自评量表、抑郁自评量表判定两组患者的精神焦虑及抑郁情况,评定心理干预效果;同时对两组患者的免疫指标和炎症细胞因子进行测定和比较。结果治疗前两组患者均伴有轻中度焦虑及抑郁。经心理干预后,干预组的焦虑及抑郁情况明显缓解,两组比较差异有统计学意义(P<0.05)。化疗前两组的各免疫因子指标之间差异无统计学意义(P>0.05)。心理干预后,干预组的自然杀伤细胞、T细胞亚群(CD3+、CD4+、CD4+/CD8+)、C反应蛋白、免疫球蛋白(Ig)G、白细胞介素(IL)-10水平升高,而IL-6和肿瘤坏死因子-α表达量降低,与对照组差异有统计学意义(P<0.05);CD8+、Ig A、Ig M两组差异无统计学意义(P>0.05)。结论心理干预可以改善结直肠癌根治术后化疗患者的焦虑、抑郁状态及免疫功能,是一种有效的辅助治疗手段。
Objective To study the influence of psychological intervention on the immune function and psychological state in patients undergoing chemotherapy after radical operation of colorectal cancer. MethodsSixty-four patients who underwent chemotherapy after eradicative resection of rectal cancer between August 2008 and August 2013 were randomly divided into control group and intervention group. Both the two groups of patients accepted conventional chemotherapy and nursing, while patients in the intervention group were also given psychological intervention. At the beginning of and 8 weeks after the therapy, self-evaluation of anxiety scale and depression selfrating scale were used to determine the psychological state（anxiety and depression） of patients in the two groups, and we evaluated the ef ect of psychological intervention. At the same time, the immune index and inl ammatory cytokines were determined and compared between the two groups. Results Before treatment, patients in both the two groups were accompanied by mild anxiety and depression. At er psychological intervention, compared with the control group, anxiety and depression of patients in the intervention group were significantly alleviated（P〈0.05）. Before chemotherapy, patients in the two groups were not statistically dif erent in the immune factor index（P〉0.05）. At er chemotherapy, compared with the control group, natural killer cells, CD3＋, CD4＋, CD4＋/CD8＋, C-reactive protein, immunoglobulin（Ig） G, interleukin（IL）-10 level of the intervention group signii cantly increased（P〈0.05）, and IL-6 and tumor necrosis factor alpha expression decreased（P〈0.05）. CD8＋, Ig A and Ig M were not signii cantly changed（P〉0.05）. Conclusion Psychological intervention can alleviate anxiety and depression and improve the immune function in patients who undergo chemotherapy at er radical operation of colorectal cancer, which is an ef ective auxiliary treatment.
出处
《华西医学》
CAS
2015年第12期2299-2302,共4页
West China Medical Journal
关键词
心理干预
肿瘤化学疗法
免疫功能
心理状态
Psychological intervention
Cancer chemotherapy
Immune function
Psychological state
