摘要
红细胞分布宽度(RDW)是反映血液循环中红细胞形态可变性的一个指标,常用RDW联合红细胞平均体积来诊断或鉴别诊断各种不同类型的贫血。近期研究揭示了RDW对冠状动脉疾病、急慢性心力衰竭、外周动脉疾病、卒中、肺栓塞和肺动脉高压的患者的预后判断价值,RDW能够预测患者短期和长期死亡和不良事件。其机制尚不明确,可能是RDW反映了一系列潜在的病理学进程,在心血管与血栓疾病中其机制主要被认为是慢性炎症反应、氧化应激和神经激素通路的激活所致。现将RDW在心血管疾病中运用的进展进行综述。
The red blood cell distribution width(RDW) is a measurement of the size variation as well as an index of the heterogeneity of the erythrocytes, which is typically used in combination with the mean corpuscular volume to troubleshoot the cause of an underlying anemia. Reliable data emerged from a variety of clinical studies have disclosed a new and unpredictable scenario in the clinical usefulness of this measure, supporting the hypothesis that RDW might be a useful parameter for gathering meaningful clinical information, either diagnostic or prognostic, on a variety of cardiovascular and thrombotic disorders. Highly significant associations have been described between RDW value and all-cause, non-cardiac and cardiac mortality in patients with coronary artery disease, acute and chronic heart failure, peripheral artery disease, stroke, pulmonary embolism and pulmonary arterial hypertension. However, it is still unclear whether anysocytosis might be the cause, or a simple epiphenomenon of an underlying disease, such as inflammation, impaired renal function, undernutrition, oxidative damage, or perhaps an element of both. Therefore, the paper reviewed the progress of RDW in cardiovascular disorders.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第23期132-136,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家自然科学基金(81060025)
关键词
心血管疾病
红细胞分布宽度
不良心血管事件
预后
Cardiovascular disease
Red blood cell distribution width
Cardiovascular adverse events
Prognosis
