摘要
目的探讨复方牛胎肝提取物(安珐特)在治疗原发性肝癌行选择性肝动脉灌注化疗栓塞(TACE)术后肝纤维化的临床疗效。方法收集2012年1月至2014年1月原发性肝癌患者40例,均于TACE术后行MRI弥散加权成像(DWI)、肝纤维化指标[透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)及IV型胶原(Ⅳ-C)]诊断为肝纤维化,将患者随机分为两组:对照组20例,TACE术后即给予甘草酸二铵胶囊常规口服;实验组20例,在常规给予甘草酸二铵胶囊口服基础上,给予安珐特口服。于治疗6个月后复查DWI、肝功能及肝纤维化指标,分析治疗前后DWI的表观弥散系数(ADC)值,HA、LN、PCⅢ、Ⅳ-C及肝功能的变化。结果实验组患者治疗6个月后较治疗前肝纤维化指标(HA、LN、PCⅢ、Ⅳ-C)明显降低(P<0.05,P<0.01),ADC值明显升高(P<0.05),肝功能(ALT、AST、TBIL、ALB)明显改善(P均<0.05);而对照组患者治疗后的肝纤维化指标、ADC值及肝功能虽有好转,但差异无统计学意义(P均>0.05)。结论安珐特可以抗原发性肝癌TACE术后肝纤维化,有助于TACE术后肝功能的恢复。
Objective To study the effect of anfate,a compound fetal cow liver extract tablet,for treatment of hepatic fibrosis after transcatheter arterial chemoembolization（ TACE） in patients with primary liver cancer. Methods Forty patients with primary liver cancer treated in our hospital from January 2012 to January 2014 were selected in this study and were randomly divided into experiment group（ n = 20） and control group（ n = 20）. All patients were confirmed as hepatic fibrosis after TACE by MRI diffusion weighted imaging（ DWI） and liver fibrosis indexes including hyaluronic acid（ HA）,laminin（ LN）,type Ⅲ collagen（ PC Ⅲ）,type IV procollagen（ Ⅳ-C）. The patients in experiment group received combination therapy of diammonium glycyrrhizinate capsules and anfate,and the patients in control group received oral diammonium glycyrrhizinate capsules alone. The DWI,liver functions including alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBIL） and albumin（ ALB） and liver fibrosis indexes were reexamined 6 months after treatment. The apparent diffusion coefficient（ ADC） of DWI,liver fibrosis and liver function indexes before and after treatment were analyzed and compared between two groups. Results Compared with pre-treatment,HA,LN,PCⅢandⅣ-C levels significantly decreased（ P 0. 05,P 0. 01）; ADC values significantly increased（ P 0. 05）; ALT,AST,TBIL and ALB levels significantly improved 6 months after treatment in experiment group（ all P 0. 05）. In control group,there were no statistical differences in the aforementioned indexes before and after treatment though they improved to some extent after treatment（ all P 0. 05）. Conclusions Anfate has antagonistic effect to hepatic fibrosis after TACE and can contribute to recovery of liver functions after TACE.
出处
《中国临床研究》
CAS
2015年第12期1557-1559,共3页
Chinese Journal of Clinical Research
基金
江苏省自然科学基金资助项目(BK2010395)
南京市医学科技发展项目(YKK12209)
关键词
肝癌
原发性
肝纤维化
肝动脉灌注化疗栓塞术
磁共振弥散加权成像
表观弥散系数
甘草酸二铵
复方牛胎肝提取物
安珐特
Liver cancer
primary
Liver fibrosis
Transcatheter arterial chemoembolization
Diffusion weighted imaging
Apparent diffusion coefficient
Diammonium glycyrrhizinate
Compound fetal cow liver extract
Anfate
