摘要
抗药基因是一种新型环境污染物,一旦被致病菌获得,将导致抗生素的临床使用失效,从而危害公共健康。抗药基因可通过转移因子在细菌间传播,加剧抗药基因的扩散效应,提升了环境健康风险性,因此抗药基因水平转移受到了越来越多的关注。本文介绍了抗药基因水平转移的分子机制,总结了不同环境中各种抗药基因水平转移途径的研究现状,并对该领域将来的研究方向提出了展望,以期为环境中抗药基因的调查评估、污染控制及合理管理提供理论参考。
Antibiotic resistance genes are a major emerging environmental pollutant of concern as they reduce the efficacy of antibiotic medical treatment and consequently threaten public health. Horizontal gene transfer of such genes between bacteria greatly accelerates the spread of antibiotic resistance, intensifying the public health risk. Thus, the mobility of antibiotic resistance genes has drawn increasing attention worldwide. This review introduces the molecular mechanisms of the horizontal transfer of antibiotic resistance genes. It is summarized that the varia- tion of these mechanisms amongst different environments. Based on this current progress, future research directions are proposed. Overall, this review aims to provide insight for the future survey and control of antibiotic resistance genes in the environment.
出处
《生态毒理学报》
CAS
CSCD
北大核心
2015年第5期11-19,共9页
Asian Journal of Ecotoxicology
基金
国家自然科学基金青年基金(51408032)
环境模拟与污染控制国家重点联合实验室(中国科学院生态环境研究中心)专项经费(14K01ESPCR)
关键词
抗药基因
水平转移
质粒
整合子
噬菌体
antibiotic resistance genes
horizontal transfer
plasmids
integrons
bacteriophage
