摘要
甲状旁腺功能减退症(甲旁减)相对罕见,手术、遗传缺陷等多种因素可导致其发病。目前有研究提示免疫因素在甲状旁腺功能减退症发病中可能具有一定作用。体液免疫方面,随着抗甲状旁腺抗体在特发性甲旁减患者中的发现,自身免疫因素在甲旁减发病机制中的作用逐渐成为国际上的研究热点。目前研究主要集中在钙敏感受体抗体和NALP5(NACHT leucine-rich-repeat protein 5)自身抗体。由于抗体异质性、检测方法、抗体阳性判断标准等原因,不同研究中这两种自身抗体在甲旁减患者中的阳性检出率差异很大。关于细胞免疫机制在甲旁减发病的作用,目前研究甚少。
Hypoparathyroidism is an uncommon endocrine-deficiency disease. Many factors such as postoperative hypoparathyroidism and genetic defects can result in hypoparathyroidism. Recently,immunology has been shown to play a vital role in the pathogenesis of hypoparathyroidism. As the discovery of antibodies to parathyroid tissue,this disease is attributable to an autoimmune process. CASR and NALP5 autoantibodies are the two possible related autoimmune antibodies. The positive rate of the two autoantibodies varied in different studies for the autoantibody heterogeneity,detection methods and the standard of judgement. However,there are few researches about the mechanism of cellular immunology in hypoparathyroidism.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2015年第4期347-351,共5页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
国家自然科学基金(81270873
81100559)
国家临床重点专科建设项目(WBYZ2011-873)
