摘要
目的未用药特发性癫痫(drug-naive idiopathic epilepsy,DNIE)是患者常规磁共振未见异常显示,且未经过抗癫痫药物治疗的一类癫痫。文中利用静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-f MRI)低频振幅方法(amplitude of low frequency fluctuation,ALFF)研究DNIE脑功能的改变,探讨其与临床变量(病程)的相关性,以提高对特发性癫痫(idiopathic epilepsy,IE)病理生理机制的理解。方法收集遵义医学院附属医院2011年1月至2014年9月门诊及住院的DNIE患者25例,其中男15例、女10例;用药特发性癫痫(drug idiopathic epilepsy,DIE)34例,其中男22例、女12例。同时招募性别、年龄、教育程度及利手与未用药组相匹配的健康志愿者25例作为对照组。采用Siemens 3.0T Trio Tim MR采集静息态数据。对原始图像预处理后进行ALFF分析,对3组数据ALFF统计脑图进行统计,并分析ALFF统计脑图与病程的相关性。结果未用药组、用药组及正常对照组3组间的ALFF统计脑图存在差异。与正常对照组比较,未用药组ALFF增加的脑区位于右颞下回、右舌回及右楔状叶,ALFF降低的脑区位于右岛叶、左海马、右中脑、右额中回、左前扣带回、左扣带回中部及右顶下小叶。与用药组比较,未用药组ALFF增加的脑区位于左枕下回和双枕中回,ALFF降低的脑区位于右额下回、左岛叶、右颞上回及右额中回。未用药组右小脑后叶、左小脑扁桃体、右舌回、左眶回、左枕中回、左胼胝体、左尾状核、左额上回、左额内侧回、右楔前叶及左额中回的ALFF与病程呈正相关,右海马旁回、右颞上回、左颞上回及右中央后回的ALFF与病程呈负相关。结论 DNIE患者存在静息态脑功能变化,且与临床变量(病程)相关,可成为癫痫病理生理机制研究的新依据。
Objective The aim of this study was to investigate the changes of brain function in patients with drug-naive idiopathic epilepsy（ DNIE） using resting-state functional MRI（ rs-f MRI）amplitude of low-frequency fluctuation（ ALFF）,analyze the correlation of abnormal brain regions with the clinical variable（ disease course）,and gain a deeper insight into the pathophysiological mechanisms of idiopathic epilepsy. Methods This study included 25 cases of DNIE（ 15 males and 10 females） and 34 cases of drug idiopathic epilepsy（ DIE,22 males and 12 females）. Another 25 healthy volunteers matched with the DNIE patients in sex,age,education and handedness were recruited as normal controls. The rsf MRI data obtained from all the subjects were processed,subjected to ALFF analysis,and compared among the DNIE,DIE,and normal control groups. The correlation was evaluated between the ALFF statistical brain mapping and the course of disease. Results Obvious differences were found in ALFF among the DNIE,DIE and control subjects. Compared with the normal controls,the DNIE patients showed increased ALFF in the right inferior temporal gyrus,right lingual gyrus and right cuneus,but decreased ALFF in the right insula,left hippocampus,right midbrain,right middle frontal gyrus,left anterior cingulated gyrus,left middle cingulate gyrus and right inferior parietal lobule. In comparison with the DIE patients,those of the DNIE group exhibited increased ALFF in the left inferior occipital gyrus,right middle occipital gyrus and left middle occipital gyrus,but decreased ALFF in the right inferior frontal gyrus,left insula,right superior temporal gyrus and right middle frontal gyrus. In the DNIE patients,the disease course was found to be correlated positively with ALFF in the right cerebellum posterior lobe,left cerebellar tonsil,right lingual gyrus,left orbital gyrus,left middle occipital gyrus,left corpus callosum,left caudate nuclear,left superior frontal gyrus,left medial frontal gyrus,right precuneus and left middle fron
出处
《医学研究生学报》
CAS
北大核心
2015年第12期1268-1275,共8页
Journal of Medical Postgraduates
基金
国家自然科学基金(81360218)
贵州省省长资金项目[黔省专合字(183)号]
贵州省科学技术基金项目[黔科合J字KLZ(2011)38号]
关键词
癫痫
特发性
功能磁共振成像
静息态
低频振荡幅度方法
Epilepsy
Idiopathic
Magnetic resonance imaging
Function magnetic resonance imaging
Resting state
Amplitude of low frequency fluctuation
