摘要
中药配伍禁忌是药物与机体相互作用本质的具体体现,是中药配伍理论的重要组成内容。毒性早期预测是药物安全性评价的重要组成部分。快速、早期获得药物可能的毒性反应数据,建立一种简单、可靠地中药配伍禁忌和中药毒性早期预测方法,是当今毒理学领域研究的重点之一。孕烷X受体(PXR)是一种配体依赖性转录因子,大量临床药物作为其配体或激活剂通过激活PXR而诱导细胞色素P450 CYP3A(CYP3A)基因表达。联合用药过程中,PXR的激活可能会增加药物发生相互作用和不良反应的风险,导致药效降低甚至产生毒性。本文从PXR-CYP3A途径为药物相互作用研究提供分子学机制,以及为中药配伍禁忌的研究和药物毒性早期预测提供了新思路。
The incompatibility of traditional Chinese medicine is an important part of traditional Chinese medicine compatibility theory, while early toxicity predetermination of traditional Chinese medi- cine is an important component of drug safety evaluation. Once a simple and reliable method to predict the compatibility of Chinese medicine and Chinese traditional medicine is established, it is possible to obtain the data of toxic reaction of Chinese herbal medicine quickly and early. Pregnane X receptor （PXR） is a ligand dependent transcription factor, acting as a ligand or activator of a large number of clinical drugs and of cytochrome P-450 CYP3A （CYP3A） gene expression induced by PXR. In the course of treatment of diseases, the activation of PXR may increase the risk of drug interactions and adverse reactions, resulting in decreased efficacy and even toxicity. This paper may provide a new method of drug toxicity predetermination depending on the PXR-CYP3A pathway.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2015年第6期967-972,共6页
Chinese Journal of Pharmacology and Toxicology
基金
国家重点基础研究发展计划(973计划)(2011CB505304)~~
